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Dive into the research topics where Edward McKee is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
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Grants
- 2 Finished
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Metabolism and toxicity of NRTIs in non-replicating tissues
McKee, E. & Mckee, E. E.
National Heart, Lung, and Blood Institute
04/20/10 → 06/30/15
Project: Research
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Mitochondrial Toxicity of Antiviral Nucleosides
National Heart, Lung, and Blood Institute
09/30/02 → 07/31/04
Project: Research
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Entecavir competitively inhibits deoxyguanosine and deoxyadenosine phosphorylation in isolated mitochondria and the perfused rat heart
Ward, A. S., Hsiung, C. H., Kesterson, D. G., Kamath, V. G. & McKee, E. E., May 1 2022, In: Journal of Biological Chemistry. 298, 5, 101876.Research output: Contribution to journal › Article › peer-review
Open Access -
Effects of zidovudine treatment on heart mRNA expression and mitochondrial DNA copy number associated with alterations in deoxynucleoside triphosphate composition in a neonatal rat model
Snowdin, J. W., Hsiung, C. H., Kesterson, D. G., Kamath, V. G. & McKee, E. E., Oct 1 2015, In: Antimicrobial Agents and Chemotherapy. 59, 10, p. 6328-6336 9 p.Research output: Contribution to journal › Article › peer-review
5 Scopus citations -
Heart mitochondrial TTP synthesis and the compartmentalization of TMP
Kamath, V. G., Hsiung, C. H., Lizenby, Z. J. & McKee, E. E., Jan 23 2015, In: Journal of Biological Chemistry. 290, 4, p. 2034-2041 8 p.Research output: Contribution to journal › Article › peer-review
Open Access7 Scopus citations -
Nonclinical and pharmacokinetic assessments to evaluate the potential of tedizolid and linezolid to affect mitochondrial function
Flanagan, S., McKee, E. E., Das, D., Tulkens, P. M., Hosako, H., Fiedler-Kelly, J., Passarell, J., Radovsky, A. & Prokocimer, P., Jan 1 2015, In: Antimicrobial Agents and Chemotherapy. 59, 1, p. 178-185 8 p.Research output: Contribution to journal › Article › peer-review
70 Scopus citations -
Exhaled aerosol pattern discloses lung structural abnormality: A sensitivity study using computational modeling and fractal analysis
Xi, J., Si, X. A., Kim, J. W., Mckee, E. & Lin, E. B., Aug 8 2014, In: PLoS ONE. 9, 8, e104682.Research output: Contribution to journal › Article › peer-review
Open Access15 Scopus citations -
Metabolism of deoxypyrimidines and deoxypyrimidine antiviral analogs in isolated brain mitochondria
McCann, K. A., Williams, D. W. & McKee, E. E., Jul 2012, In: Journal of Neurochemistry. 122, 1, p. 126-137 12 p.Research output: Contribution to journal › Article › peer-review
7 Scopus citations -
Iejimalides A and B inhibit lysosomal vacuolar H+-ATPase (V-ATPase) activity and induce S-phase arrest and apoptosis in MCF-7 cells
McHenry, P., Wang, W. L. W., Devitt, E., Kluesner, N., Davisson, V. J., McKee, E., Schweitzer, D., Helquist, P. & Tenniswood, M., Mar 1 2010, In: Journal of Cellular Biochemistry. 109, 4, p. 634-642 9 p.Research output: Contribution to journal › Article › peer-review
35 Scopus citations -
Long-term AZT exposure alters the metabolic capacity of cultured human lymphoblastoid cells
Olivero, O. A., Vazquez, I. L., Cooch, C. C., Ming, J., Keller, E., Yu, M., Borojerdi, J. P., Braun, H. M., McKee, E. & Poirier, M. C., May 2010, In: Toxicological Sciences. 115, 1, p. 109-117 9 p.Research output: Contribution to journal › Article › peer-review
10 Scopus citations -
Pyrimidine deoxynucleoside and nucleoside reverse transcriptase inhibitor metabolism in the perfused heart and isolated mitochondria
Morris, G. W., LaClair, D. D. & McKee, E. E., 2010, In: Antiviral Therapy. 15, 4, p. 587-597 11 p.Research output: Contribution to journal › Article › peer-review
4 Scopus citations -
Effects of zidovudine and stavudine on mitochondrial DNA of differentiating 3T3-F442a cells are not associated with imbalanced deoxynucleotide pools
Lynx, M. D., Laclair, D. D. & McKee, E. E., Mar 2009, In: Antimicrobial Agents and Chemotherapy. 53, 3, p. 1252-1255 4 p.Research output: Contribution to journal › Article › peer-review
6 Scopus citations -
Origin of pyrimidine deoxyribonucleotide pools in perfused rat heart: Implications for 3′-azido-3′-deoxythymidine-dependent cardiotoxicity
Morris, G. W., Iams, T. A., Slepchenko, K. G. & McKee, E. E., Sep 15 2009, In: Biochemical Journal. 422, 3, p. 513-520 8 p.Research output: Contribution to journal › Article › peer-review
24 Scopus citations -
Assessing Mitochondrial Protein Synthesis in Drug Toxicity Screening
Mckee, E. E., Jan 22 2008, Drug-Induced Mitochondrial Dysfunction. John Wiley & Sons, Inc., p. 463-472 10 p.Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review
1 Scopus citations