TY - JOUR
T1 - 8-Methyl-pyridoxatin
T2 - A novel N-hydroxy pyridone from fungus OS-F61800 that induces erythropoietin in human cells
AU - Cai, Ping
AU - Smith, David
AU - Cunningham, Bernadette
AU - Brown-Shimer, Sheryl
AU - Katz, Barry
AU - Pearce, Cedric
AU - Venables, Debra
AU - Houck, David
PY - 1999/2
Y1 - 1999/2
N2 - In the course of screening for small-molecule modulators of erythropoietin gene expression, a novel N-hydroxy pyridone was isolated from a culture of OS-F61800. Its structure was elucidated by extensive 1H and 13C NMR spectroscopic and chemical studies. This compound induced erythropoietin gene expression fivefold at a concentration of 0.3 μM, which is about threefold greater potency than our previously identified erythropoietin inducers.
AB - In the course of screening for small-molecule modulators of erythropoietin gene expression, a novel N-hydroxy pyridone was isolated from a culture of OS-F61800. Its structure was elucidated by extensive 1H and 13C NMR spectroscopic and chemical studies. This compound induced erythropoietin gene expression fivefold at a concentration of 0.3 μM, which is about threefold greater potency than our previously identified erythropoietin inducers.
UR - http://www.scopus.com/inward/record.url?scp=0033027326&partnerID=8YFLogxK
U2 - 10.1021/np980450t
DO - 10.1021/np980450t
M3 - Article
C2 - 10075801
AN - SCOPUS:0033027326
SN - 0163-3864
VL - 62
SP - 397
EP - 399
JO - Journal of Natural Products
JF - Journal of Natural Products
IS - 2
ER -