A case of recalcitrant epidermolysis bullosa acquisita responsive to rituximab therapy

Sophia K. McKinley; Jennifer T. Huang; Jennifer Tan; Daniela Kroshinsky; Stephen Gellis

doi:10.1111/pde.12006

A case of recalcitrant epidermolysis bullosa acquisita responsive to rituximab therapy

Sophia K. McKinley, Jennifer T. Huang, Jennifer Tan, Daniela Kroshinsky, Stephen Gellis

Research output: Contribution to journal › Article › peer-review

22 Scopus citations

Abstract

Epidermolysis bullosa acquisita (EBA) is an autoimmune blistering disorder that occurs infrequently in children. Although typically associated with a good prognosis in children, there are rare cases that are refractory to treatment with conventional immunosuppressive therapy. Rituximab, an anti-CD20 monoclonal antibody, has been reported to be effective in the adult form of EBA. We report a case of a child with severe and recalcitrant EBA exhibiting a sustained response to treatment with rituximab.

Original language	English
Pages (from-to)	241-244
Number of pages	4
Journal	Pediatric Dermatology
Volume	31
Issue number	2
DOIs	https://doi.org/10.1111/pde.12006
State	Published - Mar 2014
Externally published	Yes

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title = "A case of recalcitrant epidermolysis bullosa acquisita responsive to rituximab therapy",

abstract = "Epidermolysis bullosa acquisita (EBA) is an autoimmune blistering disorder that occurs infrequently in children. Although typically associated with a good prognosis in children, there are rare cases that are refractory to treatment with conventional immunosuppressive therapy. Rituximab, an anti-CD20 monoclonal antibody, has been reported to be effective in the adult form of EBA. We report a case of a child with severe and recalcitrant EBA exhibiting a sustained response to treatment with rituximab.",

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AU - Gellis, Stephen

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AB - Epidermolysis bullosa acquisita (EBA) is an autoimmune blistering disorder that occurs infrequently in children. Although typically associated with a good prognosis in children, there are rare cases that are refractory to treatment with conventional immunosuppressive therapy. Rituximab, an anti-CD20 monoclonal antibody, has been reported to be effective in the adult form of EBA. We report a case of a child with severe and recalcitrant EBA exhibiting a sustained response to treatment with rituximab.

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A case of recalcitrant epidermolysis bullosa acquisita responsive to rituximab therapy

Abstract

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