In this chapter, we present a cell-based model of angiogenesis that operates at the molecular, cellular, and tissue levels. In this new modeling framework, each endothelial cell is regarded as a viscoelastic spring and thus the vasculature is modeled as a spring network. Endothelial cells (ECs) located at the sprout tip lead the extension of blood vessels, and the endothelial cell proliferative activity is regulated by vascular endothelial growth factor (VEGF) and angiopoietins. This angiogenesis model allows for a detailed study of the relative roles of EC migration, proliferation, and maturation during blood vessel development.
|Title of host publication||Modeling Tumor Vasculature|
|Subtitle of host publication||Molecular, Cellular, and Tissue Level Aspects and Implications|
|Publisher||Springer New York|
|Number of pages||15|
|ISBN (Print)||1461400511, 9781461400516|
|State||Published - Nov 1 2012|