A cell-based model of endothelial cell migration, proliferation, and maturation in corneal angiogenesis

Trachette L. Jackson, Xiaoming Zheng

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

Abstract

In this chapter, we present a cell-based model of angiogenesis that operates at the molecular, cellular, and tissue levels. In this new modeling framework, each endothelial cell is regarded as a viscoelastic spring and thus the vasculature is modeled as a spring network. Endothelial cells (ECs) located at the sprout tip lead the extension of blood vessels, and the endothelial cell proliferative activity is regulated by vascular endothelial growth factor (VEGF) and angiopoietins. This angiogenesis model allows for a detailed study of the relative roles of EC migration, proliferation, and maturation during blood vessel development.

Original languageEnglish
Title of host publicationModeling Tumor Vasculature
Subtitle of host publicationMolecular, Cellular, and Tissue Level Aspects and Implications
PublisherSpringer New York
Pages151-165
Number of pages15
Volume9781461400523
ISBN (Electronic)9781461400523
ISBN (Print)1461400511, 9781461400516
DOIs
StatePublished - Nov 1 2012

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