A chemical reporter strategy for detecting and identifying: O -mycoloylated proteins in Corynebacterium

Herbert W. Kavunja, Brent F. Piligian, Taylor J. Fiolek, Hannah N. Foley, Temitope O. Nathan, Benjamin M. Swarts

Research output: Contribution to journalArticlepeer-review

18 Scopus citations

Abstract

Protein O-mycoloylation is a unique post-translational lipidation that was recently discovered in Corynebacterium. We describe an alkyne-modified trehalose monomycolate chemical reporter that can metabolically tag O-mycoloylated proteins in C. glutamicum, enabling their detection and identification through click chemistry.

Original languageEnglish
Pages (from-to)13795-13798
Number of pages4
JournalChemical Communications
Volume52
Issue number95
DOIs
StatePublished - 2016

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