A chemical reporter strategy for detecting and identifying O-mycoloylated proteins in Corynebacterium

Brent F. Piligian; Herbert Kavunja; Benjamin Swarts

A chemical reporter strategy for detecting and identifying O-mycoloylated proteins in Corynebacterium

Brent F. Piligian, Herbert Kavunja, Benjamin Swarts

Research output: Contribution to journal › Article › peer-review

Abstract

Protein O-mycoloylation is a unique post-translational lipidation that was recently discovered in Corynebacterium. We describe an alkyne-modified trehalose monomycolate chemical reporter that can metabolically tag O-mycoloylated proteins in C. glutamicum, enabling their detection and identification through click chemistry.

Original language	English
Pages (from-to)	13795--13798
Journal	Chem. Commun.
Volume	52
Issue number	95
State	Published - 2016

Cite this

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title = "A chemical reporter strategy for detecting and identifying O-mycoloylated proteins in Corynebacterium",

abstract = "Protein O-mycoloylation is a unique post-translational lipidation that was recently discovered in Corynebacterium. We describe an alkyne-modified trehalose monomycolate chemical reporter that can metabolically tag O-mycoloylated proteins in C. glutamicum, enabling their detection and identification through click chemistry.",

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AU - Piligian, Brent F.

AU - Kavunja, Herbert

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N2 - Protein O-mycoloylation is a unique post-translational lipidation that was recently discovered in Corynebacterium. We describe an alkyne-modified trehalose monomycolate chemical reporter that can metabolically tag O-mycoloylated proteins in C. glutamicum, enabling their detection and identification through click chemistry.

AB - Protein O-mycoloylation is a unique post-translational lipidation that was recently discovered in Corynebacterium. We describe an alkyne-modified trehalose monomycolate chemical reporter that can metabolically tag O-mycoloylated proteins in C. glutamicum, enabling their detection and identification through click chemistry.

UR - http://xlink.rsc.org/?DOI=C6CC07143K

M3 - Article

SN - 1359-7345

VL - 52

SP - 13795

EP - 13798

JO - Chem. Commun.

JF - Chem. Commun.

IS - 95

ER -

A chemical reporter strategy for detecting and identifying O-mycoloylated proteins in Corynebacterium

Abstract

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