A genomics-based classification of human lung tumors

The Clinical Lung Cancer Genome Project (CLCGP) and Network Genomic Medicine (NGM)

Research output: Contribution to journalArticlepeer-review

331 Scopus citations

Abstract

We characterized genome alterations in 1255 clinically annotated lung tumors of all histological subgroups to identify genetically defined and clinically relevant subtypes. More than 55% of all cases had at least one oncogenic genome alteration potentially amenable to specific therapeutic intervention, including several personalized treatment approaches that are already in clinical evaluation. Marked differences in the patternof genomic alterations existed between and within histological subtypes, thus challenging the original histomorphological diagnosis. Immunohistochemical studies confirmed many of these reassigned subtypes. The reassignment eliminated almost all cases of large cell carcinomas, some of which had therapeutically relevant alterations. Prospective testing of our genomics-based diagnostic algorithm in 5145 lung cancer patients enabled a genome-based diagnosis in 3863 (75%) patients, confirmed the feasibility of rational reassignments of large cell lung cancer, and led to improvement in overall survival in patients with EGFRmutant or ALK-rearranged cancers. Thus, our findings provide support for broad implementation of genomebased diagnosis of lung cancer.

Original languageEnglish
Article number209ra153
JournalScience Translational Medicine
Volume5
Issue number209
DOIs
StatePublished - Oct 30 2013

Fingerprint

Dive into the research topics of 'A genomics-based classification of human lung tumors'. Together they form a unique fingerprint.

Cite this