A metabolic basis for Alzheimer disease

George Perry, Akihiko Nunomura, Arun K. Raina, Gjumrakch Aliev, Sandra L. Siedlak, Peggy L.R. Harris, Gemma Casadesus, Robert B. Petersen, William Bligh-Glover, Elizabeth Balraj, Grace J. Petot, Mark A. Smith

Research output: Contribution to journalReview articlepeer-review

48 Scopus citations


Most studies of Alzheimer's disease (AD) have focused on a single precipitating alteration as the etiological event rather than global changes closely linked to aging. Recent evidence suggests that the most significant of these global changes are metabolic. Here we present data indicating that metabolic rate, nutrition, and neuronal size are all early indicators of AD. Understanding the cellular and molecular basis for these changes may open a new dimension to understanding AD.

Original languageEnglish
Pages (from-to)1549-1552
Number of pages4
JournalNeurochemical Research
Issue number10
StatePublished - Oct 1 2003


  • Alzheimer's disease
  • Metabolism
  • Neuronal size
  • Nutrition
  • Oxidative stress
  • Vitamins


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