A metabolic basis for Alzheimer disease

George Perry; Akihiko Nunomura; Arun K. Raina; Gjumrakch Aliev; Sandra L. Siedlak; Peggy L.R. Harris; Gemma Casadesus; Robert B. Petersen; William Bligh-Glover; Elizabeth Balraj; Grace J. Petot; Mark A. Smith

doi:10.1023/A:1025678510480

A metabolic basis for Alzheimer disease

George Perry, Akihiko Nunomura, Arun K. Raina, Gjumrakch Aliev, Sandra L. Siedlak, Peggy L.R. Harris, Gemma Casadesus, Robert B. Petersen, William Bligh-Glover, Elizabeth Balraj, Grace J. Petot, Mark A. Smith

Research output: Contribution to journal › Review article › peer-review

48 Scopus citations

Abstract

Most studies of Alzheimer's disease (AD) have focused on a single precipitating alteration as the etiological event rather than global changes closely linked to aging. Recent evidence suggests that the most significant of these global changes are metabolic. Here we present data indicating that metabolic rate, nutrition, and neuronal size are all early indicators of AD. Understanding the cellular and molecular basis for these changes may open a new dimension to understanding AD.

Original language	English
Pages (from-to)	1549-1552
Number of pages	4
Journal	Neurochemical Research
Volume	28
Issue number	10
DOIs	https://doi.org/10.1023/A:1025678510480
State	Published - Oct 1 2003

Keywords

Alzheimer's disease
Metabolism
Neuronal size
Nutrition
Oxidative stress
Vitamins

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10.1023/A:1025678510480

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title = "A metabolic basis for Alzheimer disease",

abstract = "Most studies of Alzheimer's disease (AD) have focused on a single precipitating alteration as the etiological event rather than global changes closely linked to aging. Recent evidence suggests that the most significant of these global changes are metabolic. Here we present data indicating that metabolic rate, nutrition, and neuronal size are all early indicators of AD. Understanding the cellular and molecular basis for these changes may open a new dimension to understanding AD.",

keywords = "Alzheimer's disease, Metabolism, Neuronal size, Nutrition, Oxidative stress, Vitamins",

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AU - Perry, George

AU - Nunomura, Akihiko

AU - Raina, Arun K.

AU - Aliev, Gjumrakch

AU - Siedlak, Sandra L.

AU - Harris, Peggy L.R.

AU - Casadesus, Gemma

AU - Petersen, Robert B.

AU - Bligh-Glover, William

AU - Balraj, Elizabeth

AU - Petot, Grace J.

AU - Smith, Mark A.

PY - 2003/10/1

Y1 - 2003/10/1

N2 - Most studies of Alzheimer's disease (AD) have focused on a single precipitating alteration as the etiological event rather than global changes closely linked to aging. Recent evidence suggests that the most significant of these global changes are metabolic. Here we present data indicating that metabolic rate, nutrition, and neuronal size are all early indicators of AD. Understanding the cellular and molecular basis for these changes may open a new dimension to understanding AD.

AB - Most studies of Alzheimer's disease (AD) have focused on a single precipitating alteration as the etiological event rather than global changes closely linked to aging. Recent evidence suggests that the most significant of these global changes are metabolic. Here we present data indicating that metabolic rate, nutrition, and neuronal size are all early indicators of AD. Understanding the cellular and molecular basis for these changes may open a new dimension to understanding AD.

KW - Alzheimer's disease

KW - Metabolism

KW - Neuronal size

KW - Nutrition

KW - Oxidative stress

KW - Vitamins

UR - http://www.scopus.com/inward/record.url?scp=0141705362&partnerID=8YFLogxK

U2 - 10.1023/A:1025678510480

DO - 10.1023/A:1025678510480

M3 - Review article

C2 - 14570400

AN - SCOPUS:0141705362

SN - 0364-3190

VL - 28

SP - 1549

EP - 1552

JO - Neurochemical Research

JF - Neurochemical Research

IS - 10

ER -

A metabolic basis for Alzheimer disease

Abstract

Keywords

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