A peripheral oxygen sensor provides direct activation of an identified respiratory cpg neuron in lymnaea

Harold J. Bell, Takuya Inoue, Naweed I. Syed

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

8 Scopus citations

Abstract

The mechanisms by which peripheral, hypoxia-sensitive chemosensory cells modulate the output from the respiratory central pattern generator (CPG) remain largely unknown. In order to study this topic at a fundamental level, we have developed a simple invertebrate model system, Lymnaea stagnalis wherein we have identified peripheral chemoreceptor cells (PCRCs) that relay hypoxiasensitive chemosensory information to a known respiratory CPG neuron, right pedal dorsal 1 (RPeD1). Significance of this chemosensory drive was confirmed via denervation of the peripheral sensory organ containing the PCRCs, and subsequent behavioral observation. This study provides evidence for direct synaptic connectivity between oxygen sensing PCRCs and a CPG neuron, and describes a unique model system appropriate for studying mechanisms of hypoxia-induced, respiratory plasticity from the level of an identified synapse to whole animal behavior.

Original languageEnglish
Title of host publicationIntegration in Respiratory Control
Subtitle of host publicationFrom Genes to Systems
Pages25-29
Number of pages5
DOIs
StatePublished - 2008

Publication series

NameAdvances in Experimental Medicine and Biology
Volume605
ISSN (Print)0065-2598

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