A prospective observational multicenter study of balloon angioplasty for the treatment of native and recurrent coarctation of the aorta

Kevin C. Harris, Wei Du, Collin G. Cowley, Thomas J. Forbes, Dennis W. Kim

Research output: Contribution to journalReview articlepeer-review

27 Scopus citations


Objectives Balloon angioplasty (BA) is an important treatment option for coarctation of the aorta. The congenital cardiovascular interventional study consortium (CCISC) represents a multi-institutional and multi-national effort to prospectively investigate congenital cardiac interventions. A prospective observational analysis of the efficacy and safety of balloon aortic angioplasty was conducted. Methods Data were collected prospectively from 36 CCISC sites from 2004 to 2012. One hundred and thirty patients underwent BA for native (n-=-76) and recurrent (n-=-54) coarctation. Acute, short-term, and intermediate outcomes are described for BA performed in the setting of native and recurrent coarctation of the aorta. Outcome measures included residual upper to lower extremity blood pressure gradient (ULG), use of antihypertensive medications, aortic wall injury, reobstruction, and need for reintervention. Results There was no procedural mortality. Acutely in native and recurrent coarctation, BA achieved an ULG less than 15 mm Hg in 73-80% and to less than 10 mm Hg in 54-68% of patients, respectively. At intermediate follow-up, ULG further improved, particularly for those who underwent initial reintervention for recurrent coarctation. No significant differences in aortic wall complications were seen and intervention free survival was similar for both groups. Following angioplasty, there was no significant difference in aortic wall complications; however follow up integrated imaging decreased over time. Conclusions BA is a safe and effective treatment for coarctation of the aorta acutely and at intermediate term. Although aortic injury occurred in patients with both native and recurrent coarctation, at intermediate follow-up, aneurysm was noted more often in those with initial intervention for native coarctation.

Original languageEnglish
Pages (from-to)1116-1123
Number of pages8
JournalCatheterization and Cardiovascular Interventions
Issue number7
StatePublished - Jun 1 2014
Externally publishedYes


  • angioplasty
  • coarctation
  • congenital heart disease


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