Abnormal eye movements in Creutzfeldt–Jakob disease

Michael P. Grant, Mark Cohen, Robert B. Petersen, G. Michael Halmagyi, Alan McDougall, Ronald J. Tusa, R. John Leigh

Research output: Contribution to journalArticlepeer-review

66 Scopus citations


We report 3 patients with autopsy‐proven Creutzfeldt–Jakob disease who, early in their course, developed abnormal eye movements that included periodic alternating nystagmus and slow vertical saccades. These findings suggested involvement of the cerebellar nodulus and uvula, and the brainstem reticular formation, respectively. Cerebellar ataxia was also an early manifestation and, in 1 patient, a frontal lobe brain biopsy was normal at a time when ocular motor and cerebellar signs were conspicuous. As the disease progressed, all saccades and quick phases of nystagmus were lost, but periodic alternating gaze deviation persisted. At autopsy, 2 of the 3 patients had pronounced involvement of the cerebellum, especially of the midline structures. Creutzfeldt‐Jakob disease should be considered in patients with subacute progressive neurological disease when cognitive changes are overshadowed by ocular motor findings or ataxia.

Original languageEnglish
Pages (from-to)192-197
Number of pages6
JournalAnnals of Neurology
Issue number2
StatePublished - Aug 1993


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