Accelerated human cardiac diffusion tensor imaging using simultaneous multislice imaging

Angus Z. Lau, Elizabeth M. Tunnicliffe, Robert Frost, Peter J. Koopmans, Damian J. Tyler, Matthew D. Robson

Research output: Contribution to journalArticlepeer-review

65 Scopus citations


Purpose: To demonstrate the feasibility of accelerating measurements of cardiac fiber structure using simultaneous multi-slice (SMS) imaging. Methods: SMS excitation with a blipped controlled aliasing (CAIPI) readout was incorporated into a diffusion-encoded stimulated echo pulse sequence to obtain diffusion measurements in three separate slices of the heart (8-mm thickness, 12-mm gap). A novel image entropy-based method for removing image ghosts in blipped CAIPI acquisitions is also introduced that enables SMS imaging of closely spaced slices in the heart. Results: The average retained signal-to-noise ratio (SNR) using this acquisition scheme is 70%±5%, higher than the standard 1 / √3 = 57% SNR penalty with three-fold acceleration. No significant difference was observed in the apparent diffusion coefficient and helix angle diffusion parameters between a time-equivalent conventional single-slice scan and the three-fold accelerated SMS acquisition. A 10% mean bias was observed in fractional anisotropy between single-slice and SMS acquisitions. Conclusion: The new sequence was used to obtain high-quality diffusion measurements in three closely spaced cardiac slices in a clinically feasible nine breath-hold examination. The accelerated multiband sequence is anticipated to improve quantitative measurements of cardiac microstructure by reducing the number of breath-holds required for the scan, making it practical to incorporate diffusion tensor measurements within a comprehensive clinical examination.

Original languageEnglish
Pages (from-to)995-1004
Number of pages10
JournalMagnetic Resonance in Medicine
Issue number3
StatePublished - Mar 1 2015
Externally publishedYes


  • Blipped CAIPI
  • Cardiac
  • Diffusion
  • Multiband
  • Parallel imaging
  • Simultaneous multislice


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