Acute megakaryoblastic leukemia with t(17;22)(q21;q13) and liver dysfunction

Meera B. Chitlur, Kanta Bhambhani, Anwar N. Mohamed, Yaddanapudi Ravindranath, Süreyya Savaşan

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


The t(1;22)(p13;q13) is associated with acute megakaryoblastic leukemia (AMKL) seen mostly in young infants and known to have a poor prognosis. A 5-year-old child had prolonged prothrombin and partial thromboplastin times, low albumin, and decreased vitamin K-dependent coagulation factors and factor V activities at the time of AMKL diagnosis. All of these factors normalized following chemotherapy when remission was achieved. Cytogenetic analysis revealed a female karyotype with a balanced t(17;22)(q21;q13). Here, we present an AMKL pediatric case with a novel translocation and significant hepatocellular dysfunction that resolved with chemotherapy. The t(17;22) (q21;q13) may represent a variant of t(1;22)(p13;q13).

Original languageEnglish
Pages (from-to)167-168
Number of pages2
JournalCancer Genetics and Cytogenetics
Issue number2
StatePublished - Oct 15 2004


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