TY - JOUR
T1 - Acute megakaryoblastic leukemia with t(17;22)(q21;q13) and liver dysfunction
AU - Chitlur, Meera B.
AU - Bhambhani, Kanta
AU - Mohamed, Anwar N.
AU - Ravindranath, Yaddanapudi
AU - Savaşan, Süreyya
PY - 2004/10/15
Y1 - 2004/10/15
N2 - The t(1;22)(p13;q13) is associated with acute megakaryoblastic leukemia (AMKL) seen mostly in young infants and known to have a poor prognosis. A 5-year-old child had prolonged prothrombin and partial thromboplastin times, low albumin, and decreased vitamin K-dependent coagulation factors and factor V activities at the time of AMKL diagnosis. All of these factors normalized following chemotherapy when remission was achieved. Cytogenetic analysis revealed a female karyotype with a balanced t(17;22)(q21;q13). Here, we present an AMKL pediatric case with a novel translocation and significant hepatocellular dysfunction that resolved with chemotherapy. The t(17;22) (q21;q13) may represent a variant of t(1;22)(p13;q13).
AB - The t(1;22)(p13;q13) is associated with acute megakaryoblastic leukemia (AMKL) seen mostly in young infants and known to have a poor prognosis. A 5-year-old child had prolonged prothrombin and partial thromboplastin times, low albumin, and decreased vitamin K-dependent coagulation factors and factor V activities at the time of AMKL diagnosis. All of these factors normalized following chemotherapy when remission was achieved. Cytogenetic analysis revealed a female karyotype with a balanced t(17;22)(q21;q13). Here, we present an AMKL pediatric case with a novel translocation and significant hepatocellular dysfunction that resolved with chemotherapy. The t(17;22) (q21;q13) may represent a variant of t(1;22)(p13;q13).
UR - http://www.scopus.com/inward/record.url?scp=5144228663&partnerID=8YFLogxK
U2 - 10.1016/j.cancergencyto.2004.02.019
DO - 10.1016/j.cancergencyto.2004.02.019
M3 - Article
C2 - 15474155
AN - SCOPUS:5144228663
VL - 154
SP - 167
EP - 168
JO - Cancer Genetics and Cytogenetics
JF - Cancer Genetics and Cytogenetics
SN - 0165-4608
IS - 2
ER -