TY - JOUR
T1 - Acute vaso-occlusive pain is temporally associated with the onset of menstruation in women with sickle cell disease
AU - Sharma, Deva
AU - Day, Melissa E.
AU - Stimpson, Sarah Jo
AU - Rodeghier, Mark
AU - Ghafuri, Djamila
AU - Callaghan, Michael
AU - Zaidi, Ahmar Urooj
AU - Hannan, Bryan
AU - Kassim, Adetola
AU - Zempsky, William
AU - Wellons, Melissa
AU - James, Andra
AU - Bruehl, Stephen
AU - Debaun, Michael R.
N1 - Funding Information:
The authors would like to thank the women with SCD who participated in this study. They would also like to recognize the support of the DeBaun laboratory members and Wayne State University Medical Center for their collaborative efforts, as well as the Sickle Cell Disease Association of American (SCDAA) and Cassandra Trimmel from the Sickle Cell 101 organization. Authors, M.E.D. and D.S., would like to acknowledge the Doris Duke Charitable Foundation and the Foundation for Women and Girls with Blood Disorders for their funding support, respectively.
Publisher Copyright:
© 2019 Mary Ann Liebert, Inc., publishers.
PY - 2019/2
Y1 - 2019/2
N2 - Background: Acute vaso-occlusive pain episodes in sickle cell disease (SCD) are associated with increased rates of hospitalization and early mortality. Despite the observation that women have higher rates of acute vaso-occlusive pain episodes than men, sex-specific risk factors for acute vaso-occlusive pain have not been identified. We tested the hypothesis that acute vaso-occlusive pain is temporally associated with the onset of menstruation in women with SCD. Methods: Initially, using a cross-sectional study design, we administered questionnaires, including validated measures of SCD pain frequency and severity within the last 30 days, as well as menstrual symptoms in a discovery group (n = 103). We then confirmed our findings by administering the same questionnaires online in a replication group (n = 118). A validated questionnaire was used to define dysmenorrhea. Results: In the initial discovery group, 28% (29 of 103) reported acute vaso-occlusive pain episodes temporally associated with menstruation, and 72% (74 of 103) did not. Of the 29 reporting acute vaso-occlusive pain associated with menstruation, 90% (26) and 10% (3) did and did not meet criteria for dysmenorrhea, respectively. In the replication group, 36% (43 of 118) reported acute vaso-occlusive pain temporally associated with menstruation. Of the 43 reporting acute vaso-occlusive pain associated with menstruation, 60% (26) and 40% (17) did and did not meet criteria for dysmenorrhea, respectively. Conclusions: In both the discovery and replication groups, we demonstrate that acute vaso-occlusive pain is temporally associated with the onset of menstruation that women with SCD can distinguish from dysmenorrhea.
AB - Background: Acute vaso-occlusive pain episodes in sickle cell disease (SCD) are associated with increased rates of hospitalization and early mortality. Despite the observation that women have higher rates of acute vaso-occlusive pain episodes than men, sex-specific risk factors for acute vaso-occlusive pain have not been identified. We tested the hypothesis that acute vaso-occlusive pain is temporally associated with the onset of menstruation in women with SCD. Methods: Initially, using a cross-sectional study design, we administered questionnaires, including validated measures of SCD pain frequency and severity within the last 30 days, as well as menstrual symptoms in a discovery group (n = 103). We then confirmed our findings by administering the same questionnaires online in a replication group (n = 118). A validated questionnaire was used to define dysmenorrhea. Results: In the initial discovery group, 28% (29 of 103) reported acute vaso-occlusive pain episodes temporally associated with menstruation, and 72% (74 of 103) did not. Of the 29 reporting acute vaso-occlusive pain associated with menstruation, 90% (26) and 10% (3) did and did not meet criteria for dysmenorrhea, respectively. In the replication group, 36% (43 of 118) reported acute vaso-occlusive pain temporally associated with menstruation. Of the 43 reporting acute vaso-occlusive pain associated with menstruation, 60% (26) and 40% (17) did and did not meet criteria for dysmenorrhea, respectively. Conclusions: In both the discovery and replication groups, we demonstrate that acute vaso-occlusive pain is temporally associated with the onset of menstruation that women with SCD can distinguish from dysmenorrhea.
KW - menstruation
KW - sickle cell disease
KW - vaso-occlusive pain
KW - women
UR - http://www.scopus.com/inward/record.url?scp=85061620537&partnerID=8YFLogxK
U2 - 10.1089/jwh.2018.7147
DO - 10.1089/jwh.2018.7147
M3 - Article
C2 - 30648915
AN - SCOPUS:85061620537
VL - 28
SP - 162
EP - 169
JO - Journal of Women's Health
JF - Journal of Women's Health
SN - 1540-9996
IS - 2
ER -