Abstract
Platelet-mediated thrombosis represents the initial precipitating event in the genesis of unstable angina, acute myocardial infarction, and stroke. As a result, there is considerable interest in the preclinical discovery and screening of new 'anti-platelet' therapies aimed at limiting the incidence and reoccurrence of arterial thrombosis-efforts that, to date, have largely required the use of large animal models of thrombotic occlusion. In the current report, we describe the successful development of a small-animal (rat) model of spontaneous and recurrent platelet-mediated arterial thrombosis achieved by the in vivo administration of a photoactive dye (rose bengal) followed by focal illumination with green laser light.
Original language | English |
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Pages (from-to) | 42-45 |
Number of pages | 4 |
Journal | Lasers in Medical Science |
Volume | 22 |
Issue number | 1 |
DOIs | |
State | Published - Mar 2007 |
Keywords
- Acute coronary syndromes
- Angina
- Platelet
- Rat
- Singlet oxygen
- Thrombosis