Adaptation of a photochemical method to initiate recurrent platelet-mediated thrombosis in small animals

Karin Przyklenk, Peter Whittaker

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

Platelet-mediated thrombosis represents the initial precipitating event in the genesis of unstable angina, acute myocardial infarction, and stroke. As a result, there is considerable interest in the preclinical discovery and screening of new 'anti-platelet' therapies aimed at limiting the incidence and reoccurrence of arterial thrombosis-efforts that, to date, have largely required the use of large animal models of thrombotic occlusion. In the current report, we describe the successful development of a small-animal (rat) model of spontaneous and recurrent platelet-mediated arterial thrombosis achieved by the in vivo administration of a photoactive dye (rose bengal) followed by focal illumination with green laser light.

Original languageEnglish
Pages (from-to)42-45
Number of pages4
JournalLasers in Medical Science
Volume22
Issue number1
DOIs
StatePublished - Mar 2007

Keywords

  • Acute coronary syndromes
  • Angina
  • Platelet
  • Rat
  • Singlet oxygen
  • Thrombosis

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