Advances in Tourette Syndrome. Diagnoses and Treatment.

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Abstract

Tourette syndrome (TS) is a childhood-onset neurodevelopmental disorder characterized by multiple motor tics and at least one vocal or phonic tic, and often one or more comorbid psychiatric disorders. Premonitory sensory urges before tic execution and desire for "just-right" perception are central features. The pathophysiology involves cortico-striato-thalamo-cortical circuits and possibly dopaminergic system. TS is considered a genetic disorder but the genetics is complex and likely involves rare mutations, common variants, and environmental and epigenetic factors. Treatment is multimodal and includes education and reassurance, behavioral interventions, pharmacologic, and rarely, surgical interventions.

Original languageEnglish
Pages (from-to)687-701
Number of pages15
JournalPediatric Clinics of North America
Volume62
Issue number3
DOIs
StatePublished - Jun 1 2015

Keywords

  • ADHD
  • OCD
  • Tics
  • Tourette

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