Aerodigestive adverse effects during intravenous pentamidine infusion for Pneumocystis jirovecii pneumonia prophylaxis

Süreyya Savaşan, Amy George, Catherine Sokolowski, Bettina Joi McGraw, Hillary Rademacher

Research output: Contribution to journalArticlepeer-review

Abstract

Aerodigestive adverse effects (AD-AE) during intravenous pentamidine (IV-P) infusion for Pneumocystis jiroveci pneumonia prophylaxis are uncommon in retrospective chart review studies. We conducted a survey in patients on IV-P, which included 31 specific questions. Twenty-five patients were included in the analysis; AD-AE were observed in 22 (88%) with recurrence of symptoms in 88% participants with subsequent infusions. Five leading symptoms were congestion (48%), lip tingling (32%), nausea (28%), tongue tingling (24%), vomiting, and throat swelling (17%); multiple symptoms were reported in 72% of the patients. In conclusion, AD-AE of IV-P infusion are common, self-limited, and tend to be recurrent.

Original languageEnglish
Article numbere28714
JournalPediatric Blood and Cancer
Volume68
Issue number1
DOIs
StatePublished - Jan 2021

Keywords

  • adverse reactions
  • aero-digestive
  • children
  • intravenous
  • pentamidine

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