TY - JOUR
T1 - Ambient BTEX exposure and mid-pregnancy inflammatory biomarkers in pregnant African American women
AU - Cassidy-Bushrow, Andrea E.
AU - Burmeister, Charlotte
AU - Birbeck, Johnna
AU - Chen, Yalei
AU - Lamerato, Lois
AU - Lemke, Lawrence D.
AU - Li, Jia
AU - Mor, Gil
AU - O'Leary, Brendan F.
AU - Peters, Rosalind M.
AU - Reiners, John J.
AU - Sperone, F. Gianluca
AU - Westrick, Judy
AU - Wiewiora, Evan
AU - Straughen, Jennifer K.
N1 - Funding Information:
Funding: This work was supported by the Institute for Population Sciences, Health Assessment, Administration, Services, and Economics (INPHAASE) , the Kellogg Foundation and the Center for Urban Response to Environmental Stressors NIH P30 ES020957 . The study sponsors were not involved in the design of the study, in the collection, analysis or interpretation of data, in the writing of the manuscript or in the decision to submit the article for publication.
Publisher Copyright:
© 2021 Elsevier B.V.
PY - 2021/6
Y1 - 2021/6
N2 - Air pollution is associated with preterm birth (PTB), potentially via inflammation. We recently showed the mixture benzene, toluene, ethylbenzene, and xylene (BTEX) is associated with PTB. We examined if ambient BTEX exposure is associated with mid-pregnancy inflammation in a sample of 140 African-American women residing in Detroit, Michigan. The Geospatial Determinants of Health Outcomes Consortium study collected outdoor air pollution measurements in Detroit; these data were coupled with Michigan Air Sampling Network measurements to develop monthly BTEX concentration estimates at a spatial density of 300 m2. First trimester and mid-pregnancy BTEX exposure estimates were assigned to maternal address. Mid-pregnancy (mean 21.3 ± 3.7 weeks gestation) inflammatory biomarkers (high-sensitivity C-reactive protein, interleukin [IL]-6, IL-10, IL-1β, and tumor necrosis factor-α) were measured with enzyme immunoassays. After covariate adjustment, for every 1-unit increase in first trimester BTEX, there was an expected mean increase in log-transformed IL-1β of 0.05 ± 0.02 units (P = 0.014) and an expected mean increase in log-transformed tumor necrosis factor-α of 0.07 ± 0.02 units (P = 0.006). Similarly, for every 1-unit increase in mid-pregnancy BTEX, there was a mean increase in log IL-1β of 0.06 ± 0.03 units (P = 0.027). There was no association of either first trimester or mid-pregnancy BTEX with high-sensitivity C-reactive protein, IL-10, or IL-6 (all P > 0.05). Ambient BTEX exposure is associated with inflammation in mid-pregnancy in African-American women. Future studies examining if inflammation mediates associations between BTEX exposure and PTB are needed.
AB - Air pollution is associated with preterm birth (PTB), potentially via inflammation. We recently showed the mixture benzene, toluene, ethylbenzene, and xylene (BTEX) is associated with PTB. We examined if ambient BTEX exposure is associated with mid-pregnancy inflammation in a sample of 140 African-American women residing in Detroit, Michigan. The Geospatial Determinants of Health Outcomes Consortium study collected outdoor air pollution measurements in Detroit; these data were coupled with Michigan Air Sampling Network measurements to develop monthly BTEX concentration estimates at a spatial density of 300 m2. First trimester and mid-pregnancy BTEX exposure estimates were assigned to maternal address. Mid-pregnancy (mean 21.3 ± 3.7 weeks gestation) inflammatory biomarkers (high-sensitivity C-reactive protein, interleukin [IL]-6, IL-10, IL-1β, and tumor necrosis factor-α) were measured with enzyme immunoassays. After covariate adjustment, for every 1-unit increase in first trimester BTEX, there was an expected mean increase in log-transformed IL-1β of 0.05 ± 0.02 units (P = 0.014) and an expected mean increase in log-transformed tumor necrosis factor-α of 0.07 ± 0.02 units (P = 0.006). Similarly, for every 1-unit increase in mid-pregnancy BTEX, there was a mean increase in log IL-1β of 0.06 ± 0.03 units (P = 0.027). There was no association of either first trimester or mid-pregnancy BTEX with high-sensitivity C-reactive protein, IL-10, or IL-6 (all P > 0.05). Ambient BTEX exposure is associated with inflammation in mid-pregnancy in African-American women. Future studies examining if inflammation mediates associations between BTEX exposure and PTB are needed.
KW - Air pollution
KW - BTEX
KW - Cytokines
KW - Inflammation
KW - Racial disparity
UR - http://www.scopus.com/inward/record.url?scp=85102353222&partnerID=8YFLogxK
U2 - 10.1016/j.jri.2021.103305
DO - 10.1016/j.jri.2021.103305
M3 - Article
C2 - 33725526
AN - SCOPUS:85102353222
SN - 0165-0378
VL - 145
JO - Journal of Reproductive Immunology
JF - Journal of Reproductive Immunology
M1 - 103305
ER -