Amphibians as research models for regenerative medicine

Fengyu Song, Bingbing Li, David L. Stocum

Research output: Contribution to journalReview articlepeer-review

31 Scopus citations


The ability to regenerate bone across a critical size defect would be a marked clinical advance over current methods for dealing with such structural gaps. Here, we briefly review the development of limb bones and the mandible, the regeneration of urodele limbs after amputation, and present evidence that urodele and anuran amphibians represent a valuable research model for the study of segment defect regeneration in both limb bones and mandible.

Original languageEnglish
Pages (from-to)141-150
Number of pages10
Issue number3
StatePublished - Jul 2010


  • Critical size defect
  • Endochondral bone
  • Frog
  • Growth factors
  • Intramembranous bone
  • Limb regeneration
  • Salamander
  • Scaffolds


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