Anticonvulsant effects of a leaf Extract of Ficus Exasperata vahl (Moraceae) in Mice

Eric Woode, Rosemary A. Poku, Wonder K.M. Abotsi

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

Ficus exasperata Vahl (Moraceae) is a terrestrial afro-tropical tree used as an antiepileptic remedy in African traditional medicine. This study investigated the anticonvulsant effect of a hydroalcoholic leaf extract of F, exasperata against seizures induced by pentylenetetrazole, picrotoxin or maximal electroshock in mice. The extract (30-300 mg kg-1, p.o.) significantly delayed the onset and decreased the duration of pentylenetetrazole- and picrotoxin-induced convulsions. It also caused significant reduction in the duration of maximal electroshock-induced tonic hind limb extension of mice. In addition, at some anticonvulsant doses, the extract produced motor impairment on the rotarod. The present findings strongly indicate that the leaf extract of F, exasperata has anticonvulsant properties in mice and may explain its use as an antiepileptic agent in African traditional medicine.

Original languageEnglish
Pages (from-to)405-409
Number of pages5
JournalInternational Journal of Pharmacology
Volume7
Issue number3
DOIs
StatePublished - 2011

Keywords

  • Maximal electroshock
  • Pentylenetetrazole
  • Picrotoxin
  • Rotarod
  • Seizures

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