Antimycobacterial efficacy of Andrographis paniculata leaf extracts under intracellular and hypoxic conditions

Purva Bhatter, Pooja Gupta, Poonam Daswani, Pundarikakshudu Tetali, Tannaz Birdi

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

The inhibition of the growth of Mycobacterium tuberculosis by the extracts of Andrographis paniculata has been studied using intracellular and axenic hypoxic conditions. The inhibition (confirmed using the gold standard colony forming unit assay) was found to increase with “double stimuli” or higher concentration of the extract. Organic solvent extracts were found to inhibit bacterial growth more than the aqueous extracts under microaerophilic conditions mimicked through axenic and intracellular assays. This could be further explored to evaluate the potential of the plant to be used against nonreplicating/dormant bacilli.

Original languageEnglish
Pages (from-to)3-8
Number of pages6
JournalJournal of Evidence-Based Complementary and Alternative Medicine
Volume20
Issue number1
DOIs
StatePublished - Jan 16 2015

Keywords

  • Andrographis paniculata
  • Axenic anaerobic assays
  • Drug resistant isolates
  • Intracellular assays
  • Mycobacterium tuberculosis

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