Antimycobacterial efficacy of Andrographis paniculata leaf extracts under intracellular and hypoxic conditions

Purva Bhatter; Pooja Gupta; Poonam Daswani; Pundarikakshudu Tetali; Tannaz Birdi

doi:10.1177/2156587214553303

Antimycobacterial efficacy of Andrographis paniculata leaf extracts under intracellular and hypoxic conditions

Purva Bhatter, Pooja Gupta, Poonam Daswani, Pundarikakshudu Tetali, Tannaz Birdi

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

The inhibition of the growth of Mycobacterium tuberculosis by the extracts of Andrographis paniculata has been studied using intracellular and axenic hypoxic conditions. The inhibition (confirmed using the gold standard colony forming unit assay) was found to increase with “double stimuli” or higher concentration of the extract. Organic solvent extracts were found to inhibit bacterial growth more than the aqueous extracts under microaerophilic conditions mimicked through axenic and intracellular assays. This could be further explored to evaluate the potential of the plant to be used against nonreplicating/dormant bacilli.

Original language	English
Pages (from-to)	3-8
Number of pages	6
Journal	Journal of Evidence-Based Complementary and Alternative Medicine
Volume	20
Issue number	1
DOIs	https://doi.org/10.1177/2156587214553303
State	Published - Jan 16 2015

Keywords

Andrographis paniculata
Axenic anaerobic assays
Drug resistant isolates
Intracellular assays
Mycobacterium tuberculosis

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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title = "Antimycobacterial efficacy of Andrographis paniculata leaf extracts under intracellular and hypoxic conditions",

abstract = "The inhibition of the growth of Mycobacterium tuberculosis by the extracts of Andrographis paniculata has been studied using intracellular and axenic hypoxic conditions. The inhibition (confirmed using the gold standard colony forming unit assay) was found to increase with “double stimuli” or higher concentration of the extract. Organic solvent extracts were found to inhibit bacterial growth more than the aqueous extracts under microaerophilic conditions mimicked through axenic and intracellular assays. This could be further explored to evaluate the potential of the plant to be used against nonreplicating/dormant bacilli.",

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AU - Gupta, Pooja

AU - Daswani, Poonam

AU - Tetali, Pundarikakshudu

AU - Birdi, Tannaz

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Y1 - 2015/1/16

N2 - The inhibition of the growth of Mycobacterium tuberculosis by the extracts of Andrographis paniculata has been studied using intracellular and axenic hypoxic conditions. The inhibition (confirmed using the gold standard colony forming unit assay) was found to increase with “double stimuli” or higher concentration of the extract. Organic solvent extracts were found to inhibit bacterial growth more than the aqueous extracts under microaerophilic conditions mimicked through axenic and intracellular assays. This could be further explored to evaluate the potential of the plant to be used against nonreplicating/dormant bacilli.

AB - The inhibition of the growth of Mycobacterium tuberculosis by the extracts of Andrographis paniculata has been studied using intracellular and axenic hypoxic conditions. The inhibition (confirmed using the gold standard colony forming unit assay) was found to increase with “double stimuli” or higher concentration of the extract. Organic solvent extracts were found to inhibit bacterial growth more than the aqueous extracts under microaerophilic conditions mimicked through axenic and intracellular assays. This could be further explored to evaluate the potential of the plant to be used against nonreplicating/dormant bacilli.

KW - Andrographis paniculata

KW - Axenic anaerobic assays

KW - Drug resistant isolates

KW - Intracellular assays

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Antimycobacterial efficacy of Andrographis paniculata leaf extracts under intracellular and hypoxic conditions

Abstract

Keywords

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