Application of high pressure Raman spectroscopy to bone biomechanics

Michael D. Morris, Olivia De Carmejane, Angela Carden, M. Kathleen Davis, Lars Stixrude, Mary Tecklenburg, Rupak M. Rajachar, David H. Kohn

Research output: Contribution to journalConference articlepeer-review

4 Scopus citations


Compressive stress on bone, cartilage and other tissues accompanies normal activity. While the biomechanical properties of many tissues are reasonably well-understood at many levels of structure, surprisingly little is known at the ultrastructural and crystal lattice levels. We show how the use of diamond anvil cell Raman microspectroscopy enables a deeper understanding of the response of tissue to mechanical stress. We discuss the reversible responses of deproteinated and intact bone powders to hydrostatic pressure and compare these responses to those of a model compound, synthetic carbonated apatite.

Original languageEnglish
Pages (from-to)88-97
Number of pages10
JournalProceedings of SPIE - The International Society for Optical Engineering
StatePublished - 2003
EventPROGRESS IN BIOMEDICAL OPTICS AND IMAGING: Advanced Biomedical and Clinical Diagnostic Systems - San Jose, CA, United States
Duration: Jan 26 2003Jan 28 2003


  • Biomechanics
  • Bone
  • Diamond anvil cell
  • High pressure
  • Raman spectroscopy


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