Application of high pressure Raman spectroscopy to bone biomechanics

Michael D. Morris; Olivia De Carmejane; Angela Carden; M. Kathleen Davis; Lars Stixrude; Mary Tecklenburg; Rupak M. Rajachar; David H. Kohn

doi:10.1117/12.477940

Application of high pressure Raman spectroscopy to bone biomechanics

Michael D. Morris, Olivia De Carmejane, Angela Carden, M. Kathleen Davis, Lars Stixrude, Mary Tecklenburg, Rupak M. Rajachar, David H. Kohn

https://www.cmich.edu/academics/colleges/college-science-engineering/departments-schools/chemistry-and-biochemistry

Research output: Contribution to journal › Conference article › peer-review

4 Scopus citations

Abstract

Compressive stress on bone, cartilage and other tissues accompanies normal activity. While the biomechanical properties of many tissues are reasonably well-understood at many levels of structure, surprisingly little is known at the ultrastructural and crystal lattice levels. We show how the use of diamond anvil cell Raman microspectroscopy enables a deeper understanding of the response of tissue to mechanical stress. We discuss the reversible responses of deproteinated and intact bone powders to hydrostatic pressure and compare these responses to those of a model compound, synthetic carbonated apatite.

Original language	English
Pages (from-to)	88-97
Number of pages	10
Journal	Proceedings of SPIE - The International Society for Optical Engineering
Volume	4958
DOIs	https://doi.org/10.1117/12.477940
State	Published - 2003
Event	PROGRESS IN BIOMEDICAL OPTICS AND IMAGING: Advanced Biomedical and Clinical Diagnostic Systems - San Jose, CA, United States Duration: Jan 26 2003 → Jan 28 2003

Keywords

Biomechanics
Bone
Diamond anvil cell
High pressure
Raman spectroscopy

Access to Document

10.1117/12.477940

Cite this

@article{cd4c1f53d380468d84a071c305962eb1,

title = "Application of high pressure Raman spectroscopy to bone biomechanics",

abstract = "Compressive stress on bone, cartilage and other tissues accompanies normal activity. While the biomechanical properties of many tissues are reasonably well-understood at many levels of structure, surprisingly little is known at the ultrastructural and crystal lattice levels. We show how the use of diamond anvil cell Raman microspectroscopy enables a deeper understanding of the response of tissue to mechanical stress. We discuss the reversible responses of deproteinated and intact bone powders to hydrostatic pressure and compare these responses to those of a model compound, synthetic carbonated apatite.",

keywords = "Biomechanics, Bone, Diamond anvil cell, High pressure, Raman spectroscopy",

author = "Morris, {Michael D.} and {De Carmejane}, Olivia and Angela Carden and Davis, {M. Kathleen} and Lars Stixrude and Mary Tecklenburg and Rajachar, {Rupak M.} and Kohn, {David H.}",

year = "2003",

doi = "10.1117/12.477940",

language = "English",

volume = "4958",

pages = "88--97",

journal = "Proceedings of SPIE - The International Society for Optical Engineering",

issn = "0277-786X",

note = "PROGRESS IN BIOMEDICAL OPTICS AND IMAGING: Advanced Biomedical and Clinical Diagnostic Systems ; Conference date: 26-01-2003 Through 28-01-2003",

}

TY - JOUR

T1 - Application of high pressure Raman spectroscopy to bone biomechanics

AU - Morris, Michael D.

AU - De Carmejane, Olivia

AU - Carden, Angela

AU - Davis, M. Kathleen

AU - Stixrude, Lars

AU - Tecklenburg, Mary

AU - Rajachar, Rupak M.

AU - Kohn, David H.

PY - 2003

Y1 - 2003

N2 - Compressive stress on bone, cartilage and other tissues accompanies normal activity. While the biomechanical properties of many tissues are reasonably well-understood at many levels of structure, surprisingly little is known at the ultrastructural and crystal lattice levels. We show how the use of diamond anvil cell Raman microspectroscopy enables a deeper understanding of the response of tissue to mechanical stress. We discuss the reversible responses of deproteinated and intact bone powders to hydrostatic pressure and compare these responses to those of a model compound, synthetic carbonated apatite.

AB - Compressive stress on bone, cartilage and other tissues accompanies normal activity. While the biomechanical properties of many tissues are reasonably well-understood at many levels of structure, surprisingly little is known at the ultrastructural and crystal lattice levels. We show how the use of diamond anvil cell Raman microspectroscopy enables a deeper understanding of the response of tissue to mechanical stress. We discuss the reversible responses of deproteinated and intact bone powders to hydrostatic pressure and compare these responses to those of a model compound, synthetic carbonated apatite.

KW - Biomechanics

KW - Bone

KW - Diamond anvil cell

KW - High pressure

KW - Raman spectroscopy

UR - http://www.scopus.com/inward/record.url?scp=0345282973&partnerID=8YFLogxK

U2 - 10.1117/12.477940

DO - 10.1117/12.477940

M3 - Conference article

AN - SCOPUS:0345282973

SN - 0277-786X

VL - 4958

SP - 88

EP - 97

JO - Proceedings of SPIE - The International Society for Optical Engineering

JF - Proceedings of SPIE - The International Society for Optical Engineering

T2 - PROGRESS IN BIOMEDICAL OPTICS AND IMAGING: Advanced Biomedical and Clinical Diagnostic Systems

Y2 - 26 January 2003 through 28 January 2003

ER -

Application of high pressure Raman spectroscopy to bone biomechanics

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this