Assessment of resistance to organophosphates and pyrethroids in Aedes aegypti (Diptera: Culicidae): Do synergists affect mortality?

Natalie P. Cataldo, C. Suzanne Lea, Timothy Kelley, Stephanie L. Richards

Research output: Contribution to journalArticlepeer-review

Abstract

Aedes aegypti (L.) is the primary vector of Zika, dengue, yellow fever, and chikungunya viruses. Insecticides used in mosquito control can help prevent the spread of vector-borne diseases. However, it is essential to determine insecticide resistance (IR) status before control measures are undertaken. Only the most effective insecticides should be used to avoid ineffective control and/or promotion of IR. Pyrethroids and organophosphates are the most commonly used insecticides for mosquito control. Here, the efficacy of two active ingredients (AIs; permethrin [pyrethroid], chlorpyrifos [organophosphate]), two formulated products (FPs; Biomist [AI: permethrin]) and (Mosquitomist [AI: chlorpyrifos]), and three synergists (piperonyl butoxide, diethyl maleate, S-S-S-tributyl phosphorotrithioate) was evaluated in two Ae. aegypti colonies (pyrethroid resistant and susceptible). Mosquitomist was most effective against the pyrethroid-resistant colony (100% mortality at diagnostic time). Pre-exposure to synergists did not increase the efficacy of AIs against the pyrethroid-resistant colony. Further research is needed to discover how synergists may affect the efficacy of insecticides when used on pyrethroid-resistant mosquitoes.

Original languageEnglish
Pages (from-to)1992-1996
Number of pages5
JournalJournal of Medical Entomology
Volume57
Issue number6
DOIs
StatePublished - Nov 1 2020
Externally publishedYes

Keywords

  • Ae. aegypti
  • Biomist
  • Mosquitomist
  • Organophosphate
  • Pyrethroid

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