Association between hand-foot skin reaction and effectiveness of vascular endothelial growth factor receptor tyrosine kinase inhibitors in patients with metastatic renal cell carcinoma

Yan Song, Chunxia Du, Wen Zhang, Yongkun Sun, Lin Yang, Chengxu Cui, Chi Yihebali, Aiping Zhou, Jinwan Wang, Yan Sun

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: To investigate the association between hand-foot skin reaction (HFSR) in the treatment with vascular endothelial growth factor receptor tyrosine kinase inhibitors (VEGFR-TKIs) and the effectiveness of VEGFR-TKIs. Methods: Clinical data of 155 patients with metastatic renal cell carcinoma (mRCC) treated with VEGFR-TKIs at the Cancer Hospital of Chinese Academy of Medical Sciences between January 2006 and January 2014 were retrospectively analyzed. All the patients received first-line VEGFR-TKI therapy. The treatment effectiveness and outcome between patients developing HFSR and those without HFSR were compared. Comparison of treatment response rate (RR) was performed with χ2 test, survival analysis was performed using Kaplan-Meier method, with a significance level of 0.05. Results: The median survival of all the 155 patients was 36.2 months. Among the 117 (75.5%) patients who developed HFSR, 19 patients (12.3%) had grade I HFSR, 73 (47.1%) had grade II, and 25 (16.1%) had grade III; there were no grade IV events. The RR and median progression-free survival (mPFS) in patients who did not develop HFSR were 15.8% and 6.7 months, respectively; while the RR and mPFS in patients who developed HFSR were 52.1% and 13.8 months, respectively (P < 0.001, P = 0.002). The RR and mPFS in patients with grade I HFSR were 42.1 % and 9.5 months, respectively; those in patients with grade H HFSR were 56.2% and 12.2 months, respectively, in patients with grade EI were 48.0% and 22.2 months, respectively, with statistically significant differences among the three grades of HFSR (P = 0.001, 0.009). Conclusions: HFSR might be an effective predictor for effectiveness of VEGFR-TKIs in mRCC patients. Large-sample studies are warranted to further prove these results.

Original languageEnglish
Pages (from-to)2717-2721
Number of pages5
JournalNational Medical Journal of China
Volume96
Issue number34
DOIs
StatePublished - Sep 13 2016

Keywords

  • Carcinoma
  • Hand-foot skin reaction
  • Prediction
  • Renal cell
  • Tyrosine kinase inhibitor

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