Association of Reelin gene polymorphisms with autism

Fatema J. Serajee; Hailang Zhong; A. H.M. Mahbubul Huq

doi:10.1016/j.ygeno.2005.09.008

Association of Reelin gene polymorphisms with autism

Fatema J. Serajee, Hailang Zhong, A. H.M. Mahbubul Huq

Research output: Contribution to journal › Article › peer-review

105 Scopus citations

Abstract

Genome scans indicate a linkage of autism to the chromosome 7q21-q36 region. Recent studies suggest that the Reelin gene may be one of the loci contributing to the positive linkage between chromosome 7q and autism. However, these studies were relatively small scale, using a few markers in the gene. We investigated 34 single nucleotide polymorphisms (SNPs) in the Reelin gene with an average spacing between the SNPs of 15 kb for evidence of association with autism. There were significant differences in the transmission of the alleles of exon 22 and intron 59 SNP to autistic subjects. Our findings support a role for the Reelin gene in the susceptibility to autism.

Original language	English
Pages (from-to)	75-83
Number of pages	9
Journal	Genomics
Volume	87
Issue number	1
DOIs	https://doi.org/10.1016/j.ygeno.2005.09.008
State	Published - Jan 2006

Keywords

Autism
Reelin

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10.1016/j.ygeno.2005.09.008

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title = "Association of Reelin gene polymorphisms with autism",

abstract = "Genome scans indicate a linkage of autism to the chromosome 7q21-q36 region. Recent studies suggest that the Reelin gene may be one of the loci contributing to the positive linkage between chromosome 7q and autism. However, these studies were relatively small scale, using a few markers in the gene. We investigated 34 single nucleotide polymorphisms (SNPs) in the Reelin gene with an average spacing between the SNPs of 15 kb for evidence of association with autism. There were significant differences in the transmission of the alleles of exon 22 and intron 59 SNP to autistic subjects. Our findings support a role for the Reelin gene in the susceptibility to autism.",

keywords = "Autism, Reelin",

author = "Serajee, {Fatema J.} and Hailang Zhong and {Mahbubul Huq}, {A. H.M.}",

note = "Funding Information: The study described here was supported in part by grants from the Cure Autism Now Foundation, the Child Neurology Foundation, and the Children's Research Center of Michigan. We gratefully acknowledge the resources provided by the AGRE Consortium and the participating AGRE families and acknowledge support from the Autism Genetic Resource Exchange (AGRE).",

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AU - Serajee, Fatema J.

AU - Zhong, Hailang

AU - Mahbubul Huq, A. H.M.

N1 - Funding Information: The study described here was supported in part by grants from the Cure Autism Now Foundation, the Child Neurology Foundation, and the Children's Research Center of Michigan. We gratefully acknowledge the resources provided by the AGRE Consortium and the participating AGRE families and acknowledge support from the Autism Genetic Resource Exchange (AGRE).

PY - 2006/1

Y1 - 2006/1

N2 - Genome scans indicate a linkage of autism to the chromosome 7q21-q36 region. Recent studies suggest that the Reelin gene may be one of the loci contributing to the positive linkage between chromosome 7q and autism. However, these studies were relatively small scale, using a few markers in the gene. We investigated 34 single nucleotide polymorphisms (SNPs) in the Reelin gene with an average spacing between the SNPs of 15 kb for evidence of association with autism. There were significant differences in the transmission of the alleles of exon 22 and intron 59 SNP to autistic subjects. Our findings support a role for the Reelin gene in the susceptibility to autism.

AB - Genome scans indicate a linkage of autism to the chromosome 7q21-q36 region. Recent studies suggest that the Reelin gene may be one of the loci contributing to the positive linkage between chromosome 7q and autism. However, these studies were relatively small scale, using a few markers in the gene. We investigated 34 single nucleotide polymorphisms (SNPs) in the Reelin gene with an average spacing between the SNPs of 15 kb for evidence of association with autism. There were significant differences in the transmission of the alleles of exon 22 and intron 59 SNP to autistic subjects. Our findings support a role for the Reelin gene in the susceptibility to autism.

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Association of Reelin gene polymorphisms with autism

Abstract

Keywords

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