Autologous adult bone marrow stem cell transplantation in an animal model of huntington's disease: Behavioral and morphological outcomes

Laurent Lescaudron, Divya Unni, Gary L. Dunbar

Research output: Contribution to journalArticlepeer-review

87 Scopus citations

Abstract

We investigated the effects of autologous bone marrow stem cell transplantation in a rat model of Huntington's Disease. Thirteen days after bilateral quinolinic lesions (QA), bone marrow was implanted into the damaged striatum. The ability of the transplants to reverse QA-induced cognitive deficits in the radial-arm water maze (RAWM) was examined. The transplants significantly reduced working memory deficits. Most of the transplanted cells appeared quite primitive. Because only a few cells expressed neural phenotypes, we suggest that the release of growth factors by the transplants allowed surviving cells within the caudate to function more efficiently and to facilitate other compensatory responses.

Original languageEnglish
Pages (from-to)945-956
Number of pages12
JournalInternational Journal of Neuroscience
Volume113
Issue number7
DOIs
StatePublished - Jul 1 2003

Keywords

  • Autologous transplantation
  • Bone marrow
  • Huntington's disease
  • Spatial memory
  • Stem cell
  • Striatal lesion

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