Automated analysis of respiratory behavior in extremely preterm infants and extubation readiness

C. A. Robles-Rubio, J. Kaczmarek, S. Chawla, L. Kovacs, K. A. Brown, R. E. Kearney, G. M. Sant Anna

Research output: Contribution to journalArticlepeer-review

19 Scopus citations


Background Rates of extubation failure of extremely preterm infants remain high. Analysis of breathing patterns variability during spontaneous breathing under endotracheal tube continuous positive airway pressure (ETT-CPAP) is a potential tool to predict extubation readiness. Objective To investigate if automated analysis of respiratory signals would reveal differences in respiratory behavior between infants that were successfully extubated or not. Methods Respiratory Inductive Plethysmography (RIP) signals were recorded during ETT-CPAP just prior to extubation. Signals were digitized, and analyzed using an Automated Unsupervised Respiratory Event Analysis (AUREA). Extubation failure was defined as reintubation within 72 hr. Statistical differences between infants who were successfully extubated or failed were calculated. Results A total of 56 infants were enrolled and one was excluded due to instability during the ETT-CPAP; 11 out of 55 infants studied failed extubation (20%). No differences in demographics were observed between the success and failure groups. Significant differences on the variability of some respiratory parameters or 'metrics' estimated by AUREA were observed between the 2 groups. Indeed, a simple classification using the variability of two metrics of respiratory behavior predicted extubation failure with high accuracy. Conclusion Automated analysis of respiratory behavior during a short ETT-CPAP period may help in the prediction of extubation readiness in extremely preterm infants.

Original languageEnglish
Pages (from-to)479-486
Number of pages8
JournalPediatric Pulmonology
Issue number5
StatePublished - May 1 2015
Externally publishedYes


  • extreme preterm infants
  • extubation failure
  • extubation readiness
  • respiratory behavior
  • ventilation weaning


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