Autophagy: Definition, molecular machinery, and potential role in myocardial ischemia-reperfusion injury

Yi Dong, Vishnu V. Undyala, Roberta A. Gottlieb, Robert M. Mentzer, Karin Przyklenk

Research output: Contribution to journalReview articlepeer-review

101 Scopus citations

Abstract

Autophagy is the endogenous, tightly regulated cellular "housekeeping" process responsible for the degradation of damaged and dysfunctional cellular organelles and protein aggregates. There is a growing consensus that autophagy is upregulated in the setting of myocardial ischemia-reperfusion. Moreover, emerging data suggest that autophagy may serve as an adaptive process and confer increased resistance to ischemia-reperfusion injury. Our aims in this review are to (1) provide a brief synopsis of process of autophagy (including an overview of the key molecular mediators of this catabolic process and its relationship with other cardiac signaling pathways) and (2) most importantly, summarize the current evidence for versus against the intriguing concept of autophagy-mediated cardioprotection.

Original languageEnglish
Pages (from-to)220-230
Number of pages11
JournalJournal of Cardiovascular Pharmacology and Therapeutics
Volume15
Issue number3
DOIs
StatePublished - Sep 2010

Keywords

  • apoptosis
  • autophagy
  • myocardial ischemia
  • myocardial reperfusion
  • signal transduction

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