B Cell Deficiency

Aishwarya Navalpakam, Pavadee Poowuttikul

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review


Humoral immunodeficiency disorders are characterized by B cell abnormalities which can lead to a decrease in the level and/or function of B cells and antibodies. Patients with humoral immunodeficiencies generally present with recurrent bacterial sinopulmonary or gastrointestinal infections and have a propensity for autoimmune diseases. Certain B cell deficiencies are associated with comorbidities such as bronchiectasis and chronic lung disease. Management of humoral deficiencies includes treating infections aggressively, immunoglobulin replacement therapy, and addressing complications including chronic lung disease, autoimmune disease, and malignancy. In this chapter, we will use case-based discussion to review common humoral immunodeficiencies, such as X- linked Agammaglobulinemia (XLA) and Common Variable Immunodeficiency (CVID), including their pathophysiology, clinical manifestation, diagnosis, treatment, and prognosis.

Original languageEnglish
Title of host publicationAbsolute Allergy and Immunology Board Review
PublisherSpringer International Publishing
Number of pages19
ISBN (Electronic)9783031128677
ISBN (Print)9783031128660
StatePublished - Jan 1 2022


  • Autoimmune disease
  • B cell immunodeficiency
  • Bronchiectasis
  • Chronic lung disease
  • Class switched memory B cells
  • Common variable immunodeficiency
  • Humoral immunodeficiency
  • IVIG
  • Recurrent infections
  • X-linked agammaglobulinemia


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