Basal ganglia dysfunction, working memory, and sentence comprehension in patients with Parkinson's disease

Reid L. Skeel; Bruce Crosson; Stephen E. Nadeau; James Algina; Russell M. Bauer; Eileen B. Fennell

doi:10.1016/S0028-3932(01)00026-4

Basal ganglia dysfunction, working memory, and sentence comprehension in patients with Parkinson's disease

Reid L. Skeel, Bruce Crosson, Stephen E. Nadeau, James Algina, Russell M. Bauer, Eileen B. Fennell

Psychology

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51 Scopus citations

Abstract

To investigate the role of the basal ganglia in working memory and sentence comprehension, 14 patients with Parkinson's disease (PD) were administered experimental measures of semantic and phonological working memory, and a measure of sentence comprehension, while receiving dopaminergic medications and after a period of withdrawal from these medications. An age- and education- matched control group (N=14) received the same measures. Comparison with control subjects revealed deficits in patients with PD in sentence processing regardless of medication status, but no deficits in working memory. In contrast to previous studies, withdrawal of dopaminergic medications had no significant impact on task- related working memory functions or on sentence comprehension. Results suggest that basal ganglia dysfunction does not solely account for sentence comprehension deficits seen in PD.

Original language	English
Pages (from-to)	962-971
Number of pages	10
Journal	Neuropsychologia
Volume	39
Issue number	9
DOIs	https://doi.org/10.1016/S0028-3932(01)00026-4
State	Published - Jul 23 2001

Keywords

Dopamine
Medication
Parkinson's disease
Withdrawal
Working memory

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10.1016/S0028-3932(01)00026-4

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title = "Basal ganglia dysfunction, working memory, and sentence comprehension in patients with Parkinson's disease",

abstract = "To investigate the role of the basal ganglia in working memory and sentence comprehension, 14 patients with Parkinson's disease (PD) were administered experimental measures of semantic and phonological working memory, and a measure of sentence comprehension, while receiving dopaminergic medications and after a period of withdrawal from these medications. An age- and education- matched control group (N=14) received the same measures. Comparison with control subjects revealed deficits in patients with PD in sentence processing regardless of medication status, but no deficits in working memory. In contrast to previous studies, withdrawal of dopaminergic medications had no significant impact on task- related working memory functions or on sentence comprehension. Results suggest that basal ganglia dysfunction does not solely account for sentence comprehension deficits seen in PD.",

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T1 - Basal ganglia dysfunction, working memory, and sentence comprehension in patients with Parkinson's disease

AU - Skeel, Reid L.

AU - Crosson, Bruce

AU - Nadeau, Stephen E.

AU - Algina, James

AU - Bauer, Russell M.

AU - Fennell, Eileen B.

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N2 - To investigate the role of the basal ganglia in working memory and sentence comprehension, 14 patients with Parkinson's disease (PD) were administered experimental measures of semantic and phonological working memory, and a measure of sentence comprehension, while receiving dopaminergic medications and after a period of withdrawal from these medications. An age- and education- matched control group (N=14) received the same measures. Comparison with control subjects revealed deficits in patients with PD in sentence processing regardless of medication status, but no deficits in working memory. In contrast to previous studies, withdrawal of dopaminergic medications had no significant impact on task- related working memory functions or on sentence comprehension. Results suggest that basal ganglia dysfunction does not solely account for sentence comprehension deficits seen in PD.

AB - To investigate the role of the basal ganglia in working memory and sentence comprehension, 14 patients with Parkinson's disease (PD) were administered experimental measures of semantic and phonological working memory, and a measure of sentence comprehension, while receiving dopaminergic medications and after a period of withdrawal from these medications. An age- and education- matched control group (N=14) received the same measures. Comparison with control subjects revealed deficits in patients with PD in sentence processing regardless of medication status, but no deficits in working memory. In contrast to previous studies, withdrawal of dopaminergic medications had no significant impact on task- related working memory functions or on sentence comprehension. Results suggest that basal ganglia dysfunction does not solely account for sentence comprehension deficits seen in PD.

KW - Dopamine

KW - Medication

KW - Parkinson's disease

KW - Withdrawal

KW - Working memory

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Basal ganglia dysfunction, working memory, and sentence comprehension in patients with Parkinson's disease

Abstract

Keywords

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