Bivalirudin during thrombolysis with catheter-directed tPA in a heparin-refractory patient: A case report

Katherine Regling, Michael U. Callaghan, Madhvi Rajpurkar

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Venous thromboembolism has increasing significance in hospitalized pediatric patients. Patients who have life-threatening or limb-threatening thrombotic events require thrombolysis in addition to anticoagulation. In patients who show signs of heparin resistance or heparin-induced thrombocytopenia, it is imperative to identify alternative therapeutic options. We present a child in whom bivalirudin was used for systemic anticoagulation during catheter-directed thrombolysis along with tissue plasminogen activator (Alteplase®) for the treatment of a near-occlusive organ-threatening thrombus. We also review the currently available literature on the use of combination therapy of an intravenous direct thrombin inhibitor with alteplase.

Original languageEnglish
Article numbere28094
JournalPediatric Blood and Cancer
Volume67
Issue number2
DOIs
StatePublished - Feb 1 2020

Keywords

  • anticoagulation therapy
  • coagulation
  • intensive care
  • thrombolytic
  • thrombosis

Fingerprint

Dive into the research topics of 'Bivalirudin during thrombolysis with catheter-directed tPA in a heparin-refractory patient: A case report'. Together they form a unique fingerprint.

Cite this