Bone grafts and bone graft substitutes in orthopaedic trauma surgery: A critical analysis

William G. De Long, Thomas A. Einhorn, Kenneth Koval, Michael McKee, Wade Smith, Roy Sanders, Tracy Watson

Research output: Contribution to journalReview articlepeer-review

476 Scopus citations

Abstract

Osteoinduction is a process that supports the mitogenesis of undifferentiated mesenchymal cells, leading to the formation of osteoprogenitor cells that form new bone. The human skeleton has the ability to regenerate itself as part of the repair process. Recombinant bone morphogenetic protein has osteoinductive properties, the effectiveness of which is supported by Level-1 evidence from current literature sources. Osteoconduction is a property of a matrix that supports the attachment of bone-forming cells for subsequent bone formation. Osteogenic property is a relatively new term that can be defined as the generation of bone from bone-forming cells.

Original languageEnglish
Pages (from-to)649-658
Number of pages10
JournalThe Journal of bone and joint surgery. American volume
Volume89
Issue number3
DOIs
StatePublished - Mar 2007

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