Brain calcifications induce neurological dysfunction that can be reversed by a bone drug

Jeffrey A. Loeb, Sayyed A. Sohrab, Mabubul Huq, Darren R. Fuerst

Research output: Contribution to journalArticlepeer-review

31 Scopus citations


Perivascular calcifications within the brain form in response to a variety of insults. While considered by many to be benign, these calcium phosphate deposits or "brain stones" can become large and are associated with neurological symptoms that range from seizures to parkinsonian symptoms. Here we hypothesize that the high concentrations of calcium in these deposits produce reversible, toxic effects on neurons that can be overcome with "bone" drugs that chelate solid phase calcium phosphates. We present preliminary findings that suggest a direct association between progressive neurological symptoms and brain calcification and the symptomatic improvement of seizures, headaches, and parkinsonian symptoms in patients treated with the bisphosphonate drug disodium etidronate, normally used to treat bone diseases. Future, longitudinal epidemiological studies and randomized trials will be needed to determine the true relationship between brain stones and neurological disorders as well as the utility of bisphosphonates in their prevention and treatment.

Original languageEnglish
Pages (from-to)77-81
Number of pages5
JournalJournal of the Neurological Sciences
Issue number1-2
StatePublished - Apr 15 2006


  • Bisphosphonate
  • Calcification
  • Cavernous hemangioma
  • Epilepsy
  • Etidronate
  • Headache
  • Neurocysticercosis


Dive into the research topics of 'Brain calcifications induce neurological dysfunction that can be reversed by a bone drug'. Together they form a unique fingerprint.

Cite this