TY - JOUR
T1 - Breast milk vs 24% sucrose for procedural pain relief in preterm neonates
T2 - a non-inferiority randomized controlled trial
AU - Velumula, Pradeep Kumar
AU - Elbakoush, Faesal
AU - Tabb, Carl
AU - Farooqi, Ahmad
AU - Lulic-Botica, Mirjana
AU - Jani, Sanket
AU - Natarajan, Girija
AU - Bajaj, Monika
N1 - Funding Information:
This work was supported by an institutional grant from Sarnaik Endowment Grant, Detroit Medical Center.
Publisher Copyright:
© 2022, The Author(s), under exclusive licence to Springer Nature America, Inc.
PY - 2022
Y1 - 2022
N2 - Objectives: To compare the pain scores between the two groups, breast milk (BM) and 24% sucrose, in preterm neonates undergoing automated heel lance for the blood draw. Methods: The study is designed as a randomized, single-blinded, non-inferiority trial. Infants born between 30 1/7weeks and 36 6/7 weeks of gestation were randomly assigned to receive either 24% sucrose or expressed BM. The Premature Infant Pain Profile—Revised (PIPP-R) was utilized to provide pain scores. Results: No differences were noted in the baseline characteristics between the two groups. The quantile regression estimates for PIPP-R scores during the procedure were statistically non-significant at all percentile levels of distribution (50%ile coefficient 0, 95% CI −0.49 to 0.49). Conclusion: We conclude that BM is not inferior to 24% sucrose in providing analgesia during heel lance in moderate and late preterm infants. Trial registration: This trial was registered at www.clinicaltrials.gov (identifier NCT04898881).
AB - Objectives: To compare the pain scores between the two groups, breast milk (BM) and 24% sucrose, in preterm neonates undergoing automated heel lance for the blood draw. Methods: The study is designed as a randomized, single-blinded, non-inferiority trial. Infants born between 30 1/7weeks and 36 6/7 weeks of gestation were randomly assigned to receive either 24% sucrose or expressed BM. The Premature Infant Pain Profile—Revised (PIPP-R) was utilized to provide pain scores. Results: No differences were noted in the baseline characteristics between the two groups. The quantile regression estimates for PIPP-R scores during the procedure were statistically non-significant at all percentile levels of distribution (50%ile coefficient 0, 95% CI −0.49 to 0.49). Conclusion: We conclude that BM is not inferior to 24% sucrose in providing analgesia during heel lance in moderate and late preterm infants. Trial registration: This trial was registered at www.clinicaltrials.gov (identifier NCT04898881).
UR - http://www.scopus.com/inward/record.url?scp=85125081134&partnerID=8YFLogxK
U2 - 10.1038/s41372-022-01352-2
DO - 10.1038/s41372-022-01352-2
M3 - Article
AN - SCOPUS:85125081134
JO - Journal of Perinatology
JF - Journal of Perinatology
SN - 0743-8346
ER -