C1q and phagocytosis: The perfect complement to a good meal

Manuel D. Galvan, Mallary C. Greenlee-Wacker, Suzanne S. Bohlson

Research output: Contribution to journalReview articlepeer-review

56 Scopus citations

Abstract

Complement component C1q is a member of a family of soluble proteins called defense collagens, which are important in host defense and apoptotic cell clearance. Failure to efficiently clear apoptotic cells in the absence of C1q is associated with autoimmunity. Here, we review the literature describing a central role for C1q in the enhancement of phagocyte function and focus specifically on C1q in apoptotic cell clearance. In addition, we highlight our recent findings demonstrating that C1q elicits a macrophage phenotype that is tailored specifically for clearance of apoptotic cells.

Original languageEnglish
Pages (from-to)489-497
Number of pages9
JournalJournal of Leukocyte Biology
Volume92
Issue number3
DOIs
StatePublished - Sep 2012
Externally publishedYes

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