TY - JOUR
T1 - Cardiac Manifestations in Idiopathic Inflammatory Myopathies
T2 - An Overview
AU - Jayakumar, Divya
AU - Zhang, Rui
AU - Wasserman, Amy
AU - Ash, Julia
N1 - Publisher Copyright:
© 2018 Wolters Kluwer Health, Inc. All rights reserved.
PY - 2019/5/1
Y1 - 2019/5/1
N2 - Idiopathic inflammatory myopathies are a group of autoimmune diseases that are characterized by muscle inflammation resulting in elevated muscle enzyme release and distinctive biopsy findings. This group of conditions includes polymyositis, dermatomyositis, inclusion body myositis, and necrotizing autoimmune myopathy. Although they have many similarities, the inflammatory myopathies differ in their clinical, pathological, and treatment realms. Extramuscular manifestations may involve many organs that include the skin, joints, heart, lungs, and gastrointestinal tract. Cardiovascular involvement is one of the leading causes of mortality in polymyositis and dermatomyositis. Surveillance and prevention of cardiovascular risk factors are therefore essential. In this article, we review the epidemiology, pathophysiology, clinical manifestations, diagnosis, and management of cardiovascular complications of idiopathic inflammatory myopathies with the main focus on polymyositis and dermatomyositis.
AB - Idiopathic inflammatory myopathies are a group of autoimmune diseases that are characterized by muscle inflammation resulting in elevated muscle enzyme release and distinctive biopsy findings. This group of conditions includes polymyositis, dermatomyositis, inclusion body myositis, and necrotizing autoimmune myopathy. Although they have many similarities, the inflammatory myopathies differ in their clinical, pathological, and treatment realms. Extramuscular manifestations may involve many organs that include the skin, joints, heart, lungs, and gastrointestinal tract. Cardiovascular involvement is one of the leading causes of mortality in polymyositis and dermatomyositis. Surveillance and prevention of cardiovascular risk factors are therefore essential. In this article, we review the epidemiology, pathophysiology, clinical manifestations, diagnosis, and management of cardiovascular complications of idiopathic inflammatory myopathies with the main focus on polymyositis and dermatomyositis.
KW - cardiac manifestations
KW - dermatomyositis
KW - inclusion body myositis
KW - necrotizing autoimmune myopathy
KW - polymyositis
UR - http://www.scopus.com/inward/record.url?scp=85064239884&partnerID=8YFLogxK
U2 - 10.1097/CRD.0000000000000241
DO - 10.1097/CRD.0000000000000241
M3 - Review article
C2 - 30585794
AN - SCOPUS:85064239884
VL - 27
SP - 131
EP - 137
JO - Cardiology in Review
JF - Cardiology in Review
SN - 1061-5377
IS - 3
ER -