Cardiac Manifestations in Idiopathic Inflammatory Myopathies: An Overview

Divya Jayakumar, Rui Zhang, Amy Wasserman, Julia Ash

Research output: Contribution to journalReview articlepeer-review

15 Scopus citations

Abstract

Idiopathic inflammatory myopathies are a group of autoimmune diseases that are characterized by muscle inflammation resulting in elevated muscle enzyme release and distinctive biopsy findings. This group of conditions includes polymyositis, dermatomyositis, inclusion body myositis, and necrotizing autoimmune myopathy. Although they have many similarities, the inflammatory myopathies differ in their clinical, pathological, and treatment realms. Extramuscular manifestations may involve many organs that include the skin, joints, heart, lungs, and gastrointestinal tract. Cardiovascular involvement is one of the leading causes of mortality in polymyositis and dermatomyositis. Surveillance and prevention of cardiovascular risk factors are therefore essential. In this article, we review the epidemiology, pathophysiology, clinical manifestations, diagnosis, and management of cardiovascular complications of idiopathic inflammatory myopathies with the main focus on polymyositis and dermatomyositis.

Original languageEnglish
Pages (from-to)131-137
Number of pages7
JournalCardiology in Review
Volume27
Issue number3
DOIs
StatePublished - May 1 2019

Keywords

  • cardiac manifestations
  • dermatomyositis
  • inclusion body myositis
  • necrotizing autoimmune myopathy
  • polymyositis

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