Cardioprotection 'outside the box': The evolving paradigm of remote preconditioning

Karin Przyklenk, Chad E. Darling, Eric W. Dickson, Peter Whittaker

Research output: Contribution to journalReview articlepeer-review

97 Scopus citations


Conventional ischemic preconditioning is the phenomenon whereby brief episodes of myocardial ischemia render the ischemic territory resistant to a subsequent, sustained ischemic insult. A growing body of evidence further indicates that brief ischemia applied in distant organs and tissues can also protect naïve, virgin myocardium from ischemic injury. In this review, we describe the initial observations that provided the impetus for the study of 'remote preconditioning', and summarize our current knowledge of the three facets of 'preconditioning at a distance' - intra-cardiac, inter-organ and transferred inter-cardiac preconditioning.

Original languageEnglish
Pages (from-to)149-157
Number of pages9
JournalBasic Research in Cardiology
Issue number3
StatePublished - May 2003


  • Brain
  • Kidney
  • Mesentery
  • Myocardial infarction
  • Myocardial ischemia
  • Preconditioning at a distance
  • Remote preconditioning
  • Signal transduction


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