Cardioprotection with adenosine: 'A riddle wrapped in a mystery'

Karin Przyklenk, Peter Whittaker

Research output: Contribution to journalReview articlepeer-review

5 Scopus citations

Abstract

Review of the published literature on adenosine and cardioprotection could lead one to paraphrase the famous words of Sir Winston Churchill (Radio broadcast, 1 October 1939 (in reference to Russia)) and conclude: 'I cannot forecast to you the action of adenosine. It is a riddle wrapped in a mystery inside an enigma'. That is, although it is well-established that adenosine can render cardiomyocytes resistant to lethal ischemia/reperfusion-induced injury, new and intriguing insights continue to emerge as to the mechanisms by which adenosine might limit myocardial infarct size.

Original languageEnglish
Pages (from-to)699-700
Number of pages2
JournalBritish Journal of Pharmacology
Volume145
Issue number6
DOIs
StatePublished - Jul 2005

Keywords

  • Adenosine
  • Ganglionic blockade
  • Infarct size
  • Myocardial infarction
  • Myocardial ischemia
  • Nitric oxide
  • Nitric oxide synthase
  • Preconditioning
  • Reperfusion injury
  • Signal transduction

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