CD14/16 monocyte profiling in juvenile myelomonocytic leukemia

Manisha Gadgeel, Shruti Bagla, Steven Buck, Mark Shamoun, Yaddanapudi Ravindranath

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Monocyte subset analysis by flow cytometry has been shown to be a useful diagnostic tool in chronic myelomonocytic leukemia in adults. An increase in the classical monocyte fraction (CD14++/CD16−) greater than 94.0% of total monocytes is considered highly sensitive and specific in distinguishing chronic myelomonocytic leukemia from other myeloproliferative disorders. In a pilot study of juvenile myelomonocytic leukemia cases, we noted that CD14++/CD16− monocyte fraction was >95% in de novo juvenile myelomonocytic leukemia (JMML) with somatic PTPN11 mutations but normal in those with monosomy 7 or Noonan syndrome. Monocyte subgroup profiling by itself is not diagnostic of JMML but may distinguish molecular subgroups within JMML.

Original languageEnglish
Article numbere28555
JournalPediatric Blood and Cancer
Volume67
Issue number9
DOIs
StatePublished - Sep 1 2020

Keywords

  • flow cytometry
  • juvenile myelomonocytic leukemia
  • monocyte subsets

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