@article{30fcd79288424c20b98e73d7728be229,
title = "CD36 (thrombospondin receptor) expression in childhood acute megakaryoblastic leukemia: In vitro drug sensitivity and outcome",
abstract = "The outcome for children with acute megakaryoblastic leukemia (AMKL) remains poor, except for cases associated with Down syndrome (DS). This study compared immunophenotypic and drug sensitivity patterns of childhood AMKL cases with or without DS. All DS-AMKL cases showed high expression of CD36 and were very sensitive to cytarabine and daunorubicin in vitro. In children without DS, high expression of CD36 on AMKL blasts identified a sub-group with immunophenotypic and drug sensitivity patterns similar to that of DS AMKL. Among non-DS AMKL patients, CD36-high cases had a superior outcome compared with CD36-negative cases. CD36 expression in acute myeloid leukemia cases other than AMKL was not associated with increased in vitro drug sensitivity. CD36 expression in AMKL may be an indicator of megakaryoblast maturation and chemotherapy sensitivity.",
keywords = "CD36, Cytarabine, Daunorubicin, Down syndrome, Drug sensitivity, Immunophenotype, Megakaryoblastic leukemia",
author = "S{\"u}eyya Sava{\c s}an and Steven Buck and Raimondi, {Susana C.} and Becton, {David L.} and Howard Weinstein and Myron Chang and Yaddanapudi Ravindranath",
note = "Funding Information: The authors do not have conflict of interest. This study was supported partially by funds from Leukemia Research Life, LRL, Inc., Children{\textquoteright}s Research Center of Michigan, Detroit, MI; American Lebanese Syrian Associated Charities (ALSAC), Memphis, TN; and grants (CA-29691 and CA-21765) from the National Institutes of Health; the POG grant, U10 CA 30969; Dr Ravindranath holds the Georgie Ginopolis Chair for Pediatric Cancer and Hematology, Wayne State University School of Medicine, Detroit, MI. A complete listing of grant support for research conducted by CCG and POG before initiation of the COG grant in 2003 is available online at: http://www.childrensoncologygroup. org/admin/grantinfo.htm",
year = "2006",
month = oct,
doi = "10.1080/10428190600773180",
language = "English",
volume = "47",
pages = "2076--2083",
journal = "Leukemia and Lymphoma",
issn = "1042-8194",
number = "10",
}