Cefotaxime diffusion into cerebrospinal fluid of children with meningitis

B. I. Asmar, M. C. Thirumoorthi, J. A. Buckley, D. M. Kobos, A. S. Dajani

Research output: Contribution to journalArticlepeer-review

23 Scopus citations

Abstract

Cefotaxime diffused consistently and in therapeutic levels into the cerebrospinal fluid (CSF) of 13 children successfully treated for bacterial meningitis. CSF cefotaxime levels early (6.0 μg/ml) and late (1.2 μg/ml) in treatment were severalfold the MBCs for the infecting organisms. After a single 40-mg/kg dose to each of five infants with ventriculostomies, mean CSF levels of cefotaxime were 6.4, 5.7, and 4.5 μg/ml at 2, 4, and 6 h, respectively.

Original languageEnglish
Pages (from-to)138-140
Number of pages3
JournalAntimicrobial Agents and Chemotherapy
Volume28
Issue number1
DOIs
StatePublished - 1985

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