Cefotaxime diffusion into cerebrospinal fluid of children with meningitis

B. I. Asmar, M. C. Thirumoorthi, J. A. Buckley, D. M. Kobos, A. S. Dajani

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


Cefotaxime diffused consistently and in therapeutic levels into the cerebrospinal fluid (CSF) of 13 children successfully treated for bacterial meningitis. CSF cefotaxime levels early (6.0 μg/ml) and late (1.2 μg/ml) in treatment were severalfold the MBCs for the infecting organisms. After a single 40-mg/kg dose to each of five infants with ventriculostomies, mean CSF levels of cefotaxime were 6.4, 5.7, and 4.5 μg/ml at 2, 4, and 6 h, respectively.

Original languageEnglish
Pages (from-to)138-140
Number of pages3
JournalAntimicrobial Agents and Chemotherapy
Issue number1
StatePublished - 1985


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