Ceftolozane/Tazobactam Treatment of Multidrug-resistant Pseudomonas aeruginosa Infections in Children

Leah Molloy; Ibrahim Abdulhamid; Ruma Srivastava; Jocelyn Y. Ang

doi:10.1097/INF.0000000000002593

Ceftolozane/Tazobactam Treatment of Multidrug-resistant Pseudomonas aeruginosa Infections in Children

Leah Molloy, Ibrahim Abdulhamid, Ruma Srivastava, Jocelyn Y. Ang

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

The clinical use, safety and effectiveness of ceftolozane/tazobactam among 13 patients 3 months to 19 years of age infected with multidrug-resistant Pseudomonas aeruginosa are described. All but one patient achieved clinical cure after initial treatment. Adverse drug events attributed to treatment included transaminitis and neutropenia which occurred in 2 patients and resolved upon dose reduction.

Original language	English
Pages (from-to)	419-420
Number of pages	2
Journal	Pediatric Infectious Disease Journal
Volume	39
Issue number	5
DOIs	https://doi.org/10.1097/INF.0000000000002593
State	Published - May 1 2020

Keywords

Pseudomonas aeruginosa
ceftolozane/tazobactam
multidrug-resistant

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1097/INF.0000000000002593

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title = "Ceftolozane/Tazobactam Treatment of Multidrug-resistant Pseudomonas aeruginosa Infections in Children",

abstract = "The clinical use, safety and effectiveness of ceftolozane/tazobactam among 13 patients 3 months to 19 years of age infected with multidrug-resistant Pseudomonas aeruginosa are described. All but one patient achieved clinical cure after initial treatment. Adverse drug events attributed to treatment included transaminitis and neutropenia which occurred in 2 patients and resolved upon dose reduction.",

keywords = "Pseudomonas aeruginosa, ceftolozane/tazobactam, multidrug-resistant",

author = "Leah Molloy and Ibrahim Abdulhamid and Ruma Srivastava and Ang, {Jocelyn Y.}",

note = "Funding Information: J.Y.A. has received institutional research funding from Merck & Co., Inc. The other authors have no conflicts of interest to disclose. Publisher Copyright: Copyright {\textcopyright} 2020 Wolters Kluwer Health, Inc. All rights reserved.",

year = "2020",

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T1 - Ceftolozane/Tazobactam Treatment of Multidrug-resistant Pseudomonas aeruginosa Infections in Children

AU - Molloy, Leah

AU - Abdulhamid, Ibrahim

AU - Srivastava, Ruma

AU - Ang, Jocelyn Y.

N1 - Funding Information: J.Y.A. has received institutional research funding from Merck & Co., Inc. The other authors have no conflicts of interest to disclose. Publisher Copyright: Copyright © 2020 Wolters Kluwer Health, Inc. All rights reserved.

PY - 2020/5/1

Y1 - 2020/5/1

N2 - The clinical use, safety and effectiveness of ceftolozane/tazobactam among 13 patients 3 months to 19 years of age infected with multidrug-resistant Pseudomonas aeruginosa are described. All but one patient achieved clinical cure after initial treatment. Adverse drug events attributed to treatment included transaminitis and neutropenia which occurred in 2 patients and resolved upon dose reduction.

AB - The clinical use, safety and effectiveness of ceftolozane/tazobactam among 13 patients 3 months to 19 years of age infected with multidrug-resistant Pseudomonas aeruginosa are described. All but one patient achieved clinical cure after initial treatment. Adverse drug events attributed to treatment included transaminitis and neutropenia which occurred in 2 patients and resolved upon dose reduction.

KW - Pseudomonas aeruginosa

KW - ceftolozane/tazobactam

KW - multidrug-resistant

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JO - Pediatric Infectious Disease Journal

JF - Pediatric Infectious Disease Journal

IS - 5

ER -

Ceftolozane/Tazobactam Treatment of Multidrug-resistant Pseudomonas aeruginosa Infections in Children

Abstract

Keywords

UN SDGs

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