Ceftriaxone induced hemolysis complicated by acute renal failure

Gaurav Kapur, Rudolph P. Valentini, Tej K. Mattoo, Indira Warrier, Abubakr A. Imam

Research output: Contribution to journalArticlepeer-review

22 Scopus citations


Over the last decade, second and third generation cephalosporins have been the most common drugs causing hemolytic anemia (HA). Of these cases, 20% have been attributed to ceftriaxone. The clinical presentation of ceftriaxone-induced HA is usually abrupt with sudden onset of pallor, tachypnea, cardio-respiratory arrest and shock. Acute renal failure (ARF) has been reported in 41% of such cases with a high fatality rate. We report a pediatric patient with ARF complicating ceftriaxone-induced HA who survived. Ceftriaxone is a commonly used drug, and early recognition of HA and institution of supportive care, including dialysis is likely to improve the outcome.

Original languageEnglish
Pages (from-to)139-142
Number of pages4
JournalPediatric Blood and Cancer
Issue number1
StatePublished - Jan 2008


  • Acute renal failure (ARF)
  • Ceftriaxone
  • Hemolytic anemia (HA)


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