TY - JOUR
T1 - Ceftriaxone induced hemolysis complicated by acute renal failure
AU - Kapur, Gaurav
AU - Valentini, Rudolph P.
AU - Mattoo, Tej K.
AU - Warrier, Indira
AU - Imam, Abubakr A.
PY - 2008/1
Y1 - 2008/1
N2 - Over the last decade, second and third generation cephalosporins have been the most common drugs causing hemolytic anemia (HA). Of these cases, 20% have been attributed to ceftriaxone. The clinical presentation of ceftriaxone-induced HA is usually abrupt with sudden onset of pallor, tachypnea, cardio-respiratory arrest and shock. Acute renal failure (ARF) has been reported in 41% of such cases with a high fatality rate. We report a pediatric patient with ARF complicating ceftriaxone-induced HA who survived. Ceftriaxone is a commonly used drug, and early recognition of HA and institution of supportive care, including dialysis is likely to improve the outcome.
AB - Over the last decade, second and third generation cephalosporins have been the most common drugs causing hemolytic anemia (HA). Of these cases, 20% have been attributed to ceftriaxone. The clinical presentation of ceftriaxone-induced HA is usually abrupt with sudden onset of pallor, tachypnea, cardio-respiratory arrest and shock. Acute renal failure (ARF) has been reported in 41% of such cases with a high fatality rate. We report a pediatric patient with ARF complicating ceftriaxone-induced HA who survived. Ceftriaxone is a commonly used drug, and early recognition of HA and institution of supportive care, including dialysis is likely to improve the outcome.
KW - Acute renal failure (ARF)
KW - Ceftriaxone
KW - Hemolytic anemia (HA)
UR - http://www.scopus.com/inward/record.url?scp=36849076644&partnerID=8YFLogxK
U2 - 10.1002/pbc.20839
DO - 10.1002/pbc.20839
M3 - Article
C2 - 16602117
AN - SCOPUS:36849076644
SN - 1545-5009
VL - 50
SP - 139
EP - 142
JO - Pediatric Blood and Cancer
JF - Pediatric Blood and Cancer
IS - 1
ER -