Celery root extract as an inducer of mania induction in a patient on venlafaxine and St John’s Wort

Zaira Khalid, Ferdnand C. Osuagwu, Bilal Shah, Nikita Roy, James E. Dillon, Ronald Bradley

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

Celery root belongs to a group of plants classified as the umbelliferous family, which contains phytoestrogens. Phytoestrogens are structurally similar to estrogen as they share a pair of hydroxyl groups and phenolic ring, which enables them to bind to estrogen receptors directly, making them a herbal remedy for low estrogen states such as menopause. We present a case of a female patient with depression who was stabilized on venlafaxine and St John’s Wort, and who developed a manic episode due to elevated serum venlafaxine levels after she started taking celery extracts for menopausal related issues. We proffer a hypothesis for this unusual occurrence.

Original languageEnglish
Pages (from-to)682-683
Number of pages2
JournalPostgraduate Medicine
Volume128
Issue number7
DOIs
StatePublished - Oct 2 2016

Keywords

  • Celery root
  • St John’s worth
  • bipolar disorder
  • mania
  • venlafaxine

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