TY - JOUR
T1 - Cellular mechanisms of infarct size reduction with ischemic preconditioning. Role of calcium?
AU - Przyklenk, Karin
AU - Simkhovich, Boris Z.
AU - Bauer, Barbara
AU - Hata, Katsuya
AU - Zhao, Lin
AU - Elliott, Gary T.
AU - Kloner, Robert A.
PY - 1999
Y1 - 1999
N2 - Brief episodes of ischemia protect or 'precondition' the heart and reduce infarct size caused by a subsequent sustained ischemic insult. Despite a decade of intensive investigation, the cellular mechanism(s) responsible for this paradoxical protection remain poorly understood. In this review, we focus on the emerging concept that alterations in intracellular calcium homeostasis may participate in either triggering and/or mediating infarct size reduction with preconditioning.
AB - Brief episodes of ischemia protect or 'precondition' the heart and reduce infarct size caused by a subsequent sustained ischemic insult. Despite a decade of intensive investigation, the cellular mechanism(s) responsible for this paradoxical protection remain poorly understood. In this review, we focus on the emerging concept that alterations in intracellular calcium homeostasis may participate in either triggering and/or mediating infarct size reduction with preconditioning.
UR - http://www.scopus.com/inward/record.url?scp=0032790013&partnerID=8YFLogxK
U2 - 10.1111/j.1749-6632.1999.tb09236.x
DO - 10.1111/j.1749-6632.1999.tb09236.x
M3 - Article
C2 - 10415532
AN - SCOPUS:0032790013
SN - 0077-8923
VL - 874
SP - 192
EP - 210
JO - Annals of the New York Academy of Sciences
JF - Annals of the New York Academy of Sciences
ER -