Cellular mechanisms of infarct size reduction with ischemic preconditioning. Role of calcium?

Karin Przyklenk, Boris Z. Simkhovich, Barbara Bauer, Katsuya Hata, Lin Zhao, Gary T. Elliott, Robert A. Kloner

Research output: Contribution to journalArticlepeer-review

25 Scopus citations

Abstract

Brief episodes of ischemia protect or 'precondition' the heart and reduce infarct size caused by a subsequent sustained ischemic insult. Despite a decade of intensive investigation, the cellular mechanism(s) responsible for this paradoxical protection remain poorly understood. In this review, we focus on the emerging concept that alterations in intracellular calcium homeostasis may participate in either triggering and/or mediating infarct size reduction with preconditioning.

Original languageEnglish
Pages (from-to)192-210
Number of pages19
JournalAnnals of the New York Academy of Sciences
Volume874
DOIs
StatePublished - 1999

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