Cellular Processing of Factor VIII and Factor IX

Michael U. Callaghan, Randal J. Kaufman

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

2 Scopus citations
Original languageEnglish
Title of host publicationTextbook of Hemophilia
Subtitle of host publicationSecond Edition
Number of pages11
ISBN (Print)9781405169141
StatePublished - Aug 13 2010


  • Asparagine - and serine/threonine-linked glycosylation
  • Blood coagulation, plasma and cellular blood components - functions in fluid phase
  • Cellular processing of factor VIII and factor IX
  • Chaperone - assisted factor VIII folding
  • Crystal structure of B-domain-less factor VIII - triangular heterotrimer of three A domains
  • Eukaryotic cells, extensive machinery - modifying polypeptides transiting secretory compartment
  • Factor IX and hemophilia B
  • Factor VIII and factor V - homologous glycoproteins
  • Factor VIII and factor V, conserving disulfide bonding pattern with two disulfide bonds
  • Sulfate addition to tyrosine as O4-sulfate ester - post-translational modification of secretory proteins


Dive into the research topics of 'Cellular Processing of Factor VIII and Factor IX'. Together they form a unique fingerprint.

Cite this