Characterization of a novel HLA-B*39:01:01-related allele, HLA-B*39:130, by cloning and phasing

L. X. Li, W. Tian, F. M. Zhu, W. Y. Wang, J. H. Cai

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

A novel HLA-B*39:01:01-related variant, HLA-B*39:130, has been identified in a normal individual of Han ethnicity in Hunan province, southern China. Following Sanger polymerase chain reaction–sequence-based typing (PCR-SBT), this new allele was further confirmed by cloning, phasing and sequencing. Aligned with HLA-B*39:01:01, HLA-B*39:130 has a nonsynonymous thymine substitution at nucleotide position 94 in exon 4, resulting in amino acid change from threonine to isoleucine at codon 214 (ACA→ATA) of the mature HLA-BmRNA molecule.

Original languageEnglish
Pages (from-to)356-358
Number of pages3
JournalInternational Journal of Immunogenetics
Volume44
Issue number6
DOIs
StatePublished - Dec 2017
Externally publishedYes

Keywords

  • HLA-B*39:130
  • cloning
  • phasing
  • sequence-based typing
  • southern Chinese Han population

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