TY - JOUR
T1 - Chlorinated dibenzo-p-dioxins, dibenzofurans, and biphenyl profiles of workers with trichlorophenol and pentachlorophenol exposures
AU - Collins, James J.
AU - Bodner, Kenneth
AU - Haidar, Salma
AU - Wilken, Michael
AU - Burns, Carol J.
AU - Lamparski, Les L.
AU - Budinsky, Robert A.
AU - Martin, Greg D.
AU - Carson, Michael L.
N1 - Funding Information:
This research was funded by The Dow Chemical Company. We would like to thank members of the Dow Chemical’s Health Services staff including Melody Raab, Sandy Murray, Lisa Pressnell, and Kathleen Collins, for arranging the appointments, and drawing and separating the blood, members of the Dow Chemical’s Toxicology Environmental Research Center including Kathy Brzak and Melissa Mielke for storing, packing, and shipping the sera, Tim Bell of Dow Chemical’s Toxicology Environmental Research Center for conducting laboratory audits and assuring study quality, and members of the Epidemiology Group including Brenda Jammer, Monica Chau, Tiffany Wrzesinski, Alisa Caspers, Jamye Haring and Erica Campbell for statistical sampling, data input, and mailings. This study conduct was pursuant to review and oversight by a Human Subjects Review Board.
PY - 2008/8
Y1 - 2008/8
N2 - We examined the serum lipid adjusted levels of 2,3,7,8-substituted chlorinated dioxins and furans, and four coplanar PCBs for 98 workers. We found workers who worked only in the trichlorophenol units had mean lipid adjusted 2,3,7,8-TCDD levels of 36.8 ppt significantly higher (p < 0.05) than 6.0 ppt in the reference group. Workers who worked only in the pentachlorophenol units had mean lipid adjusted levels for 123478-HxCDD of 14.8 ppt, 123678-HxCDD of 156.4 ppt,123789-HxCDD of 23.7 ppt, 1234678-HpCDD of 234.6 ppt, and OCDD of 2,778.2 ppt significantly higher (p < 0.05) than the reference group levels for the same congeners of 7.5, 71.8, 8.0, 67.5, and 483.2 ppt, respectively. While we did find 12378-PeCDD levels higher than the reference group in trichlorophenol and pentachlorophenol workers, the differences are small, and could be attributed to normal variation. All furan levels among the trichlorophenol or pentachlorophenol only workers were not significantly different than the reference group. Workers with both trichlorophenol and pentachlorophenol exposures had mean dioxin levels consistent with complex chlorophenol exposures. Tradesmen who worked throughout the plant had congener profiles consistent with both trichlorophenol and pentachlorophenol exposures. PCB 169, 23478-PeCDF, 123478-HxCDF, and 123678-HxCDF levels were also significantly greater (p < 0.05) in these tradesmen than in the reference group. We found distinct patterns of dioxin congeners many years after exposure among workers with different chlorophenol exposures. We were effectively able to distinguish past trichlorophenol exposures from pentachlorophenol exposures based on differing serum dioxin profiles among workers.
AB - We examined the serum lipid adjusted levels of 2,3,7,8-substituted chlorinated dioxins and furans, and four coplanar PCBs for 98 workers. We found workers who worked only in the trichlorophenol units had mean lipid adjusted 2,3,7,8-TCDD levels of 36.8 ppt significantly higher (p < 0.05) than 6.0 ppt in the reference group. Workers who worked only in the pentachlorophenol units had mean lipid adjusted levels for 123478-HxCDD of 14.8 ppt, 123678-HxCDD of 156.4 ppt,123789-HxCDD of 23.7 ppt, 1234678-HpCDD of 234.6 ppt, and OCDD of 2,778.2 ppt significantly higher (p < 0.05) than the reference group levels for the same congeners of 7.5, 71.8, 8.0, 67.5, and 483.2 ppt, respectively. While we did find 12378-PeCDD levels higher than the reference group in trichlorophenol and pentachlorophenol workers, the differences are small, and could be attributed to normal variation. All furan levels among the trichlorophenol or pentachlorophenol only workers were not significantly different than the reference group. Workers with both trichlorophenol and pentachlorophenol exposures had mean dioxin levels consistent with complex chlorophenol exposures. Tradesmen who worked throughout the plant had congener profiles consistent with both trichlorophenol and pentachlorophenol exposures. PCB 169, 23478-PeCDF, 123478-HxCDF, and 123678-HxCDF levels were also significantly greater (p < 0.05) in these tradesmen than in the reference group. We found distinct patterns of dioxin congeners many years after exposure among workers with different chlorophenol exposures. We were effectively able to distinguish past trichlorophenol exposures from pentachlorophenol exposures based on differing serum dioxin profiles among workers.
KW - Dioxin
KW - Furans
KW - PCBs
KW - Pentachlorophenol
KW - Serum
KW - Trichlorophenol
UR - http://www.scopus.com/inward/record.url?scp=48849093134&partnerID=8YFLogxK
U2 - 10.1016/j.chemosphere.2007.12.034
DO - 10.1016/j.chemosphere.2007.12.034
M3 - Article
C2 - 18442847
AN - SCOPUS:48849093134
VL - 73
SP - S284-S289
JO - Chemosphere
JF - Chemosphere
SN - 0045-6535
IS - 1 SUPPL.
ER -