Clinical and neuroimaging findings in neonatal herpes simplex virus infection

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23 Scopus citations


In a retrospective review of infants with neonatal herpes simplex virus disease (n = 29), we found bilateral multilobar (n = 8), pontine (n = 3), thalamic (n = 6), and internal capsule and corticospinal tract (n = 5) involvement on magnetic resonance imaging (MRI). Diffusion-weighted imaging (n = 6) performed early revealed additional involvement than detected by conventional MRI. Neurodevelopmental sequelae were correlated with MRI abnormalities. Our findings demonstrate that MRI, including diffusion-weighted imaging, is a valuable prognostic adjunct in neonatal herpes simplex virus disease.

Original languageEnglish
Pages (from-to)404-407.e1
JournalJournal of Pediatrics
Issue number2
StatePublished - Aug 2014


  • CNS
  • CSF
  • CT
  • Central nervous system
  • Cerebrospinal fluid
  • Computed tomography
  • DWI
  • Diffusion-weighted imaging
  • HSV
  • Herpes simplex virus
  • MRI
  • Magnetic resonance imaging


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