Clinical Aspects of Preconditioning and Implications for the Cardiac Surgeon

Robert A. Kloner, Karin Przyklenk, Thomas Shook, Ray V. Matthews, Steven Burstein, David S. Cannom, Nidal Isber, Gregory Kay

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


Ischemic preconditioning is one of the most powerful means to reduce myocardial ischemic cell death in the experimental laboratory. Data are now emerging suggesting that ischemic preconditioning also can occur in the human heart. Studies performed on human myocardial biopsies, angioplasty studies, clinical studies assessing acute tolerance to angina, and some studies evaluating the effect of angina prior to myocardial infarction, lend support to the concept that the human heart can be preconditioned. The ultimate objective is to develop preconditioning‐mimetic agents that can be administered prophylactically prior to the time of cardiopulmonary bypass surgery or administered to hearts that have been harvested for transplant in order to better preserve the ischemically jeopardized myocyte.

Original languageEnglish
Pages (from-to)369-375
Number of pages7
JournalJournal of Cardiac Surgery
StatePublished - Jul 1995


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